{"id":"W2034442061","doi":"10.1371/journal.pone.0056962","title":"A cis-Acting Element Present within the gag Open Reading Frame Negatively Impacts on the Activity of the HIV-1 IRES","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Comisión Nacional de Investigación Científica y Tecnológica; Canadian Institutes of Health Research; McGill University","keywords":"Internal ribosome entry site; Translation (biology); Open reading frame; Eukaryotic translation; Cell biology; Biology; Heterologous; Messenger RNA; Protein biosynthesis; Virology; Molecular biology; Genetics; Gene; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434128,0.0003453126,0.0003323124,0.0001175765,0.0001301907,0.000309205,0.0001552489,0.000235121,0.001637687],"category_scores_gemma":[0.0001830254,0.0001357194,0.0001989055,0.00007748792,0.0002301501,0.0001513431,0.0001800251,0.0005868831,0.0003635254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162515,"about_ca_system_score_gemma":0.0001892289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607957,"about_ca_topic_score_gemma":0.0004003933,"domain_scores_codex":[0.9998322,0.00004164971,0.00001529819,0.00002698747,0.00004670414,0.00003724906],"domain_scores_gemma":[0.9998555,0.00005876412,0.00002452771,0.00001887033,0.00001618427,0.00002609734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115241,0.00001912349,0.0001180177,0.00002322115,0.000002757384,0.00003285362,0.00000457498,0.00003735392,0.9989042,0.00003536951,0.00001678317,0.0006905076],"study_design_scores_gemma":[0.000006306997,0.0002269211,0.002643051,0.000005534068,0.00001211293,0.0001822118,0.00001099417,0.0003496277,0.9957503,0.00002063444,0.000788604,0.000003728019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962213,0.00150985,0.0007159315,0.00006842619,0.00003436923,0.000009490632,0.0001576382,0.00003390228,0.001249081],"genre_scores_gemma":[0.9970711,0.0006168271,0.0009935973,0.00004310885,0.00001139281,0.00001187543,0.0002813136,0.00001381454,0.0009569613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001637687,"threshold_uncertainty_score":0.005478621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0807191315502264,"score_gpt":0.2895488625051234,"score_spread":0.208829730954897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}