{"id":"W2034457721","doi":"10.1371/journal.pone.0097797","title":"Serum Stability and Physicochemical Characterization of a Novel Amphipathic Peptide C6M1 for SiRNA Delivery","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Small interfering RNA; Dynamic light scattering; Peptide; Circular dichroism; Chemistry; Biophysics; Random coil; Amphiphile; Nucleic acid; Gene knockdown; Oligonucleotide; RNA; Molecular biology; Biochemistry; RNase P; Förster resonance energy transfer; Fluorescence; Biology; Materials science; Gene; Nanotechnology; Nanoparticle; Copolymer; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001123811,0.00009025387,0.0001549447,0.00001576505,0.00002635809,0.000008788619,0.00007944756,0.00008979295,0.000006175801],"category_scores_gemma":[0.00009436061,0.00009102611,0.00004689556,0.00002695953,0.00005798726,0.000005575604,0.00005643139,0.00004035396,0.000001191055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004797252,"about_ca_system_score_gemma":0.00001968634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004563614,"about_ca_topic_score_gemma":0.000004866739,"domain_scores_codex":[0.9993967,0.0000181529,0.0001528316,0.00022931,0.00008181706,0.0001211197],"domain_scores_gemma":[0.9995047,0.00001663077,0.00007578382,0.0001978017,0.0001643057,0.00004080519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118244,0.0004953535,0.003145002,0.0001340576,0.00006069489,2.533088e-8,0.00004174658,3.228679e-7,0.9954851,0.00002254212,0.000008589904,0.000494764],"study_design_scores_gemma":[0.0004551025,0.0003530345,0.006844462,0.0000523946,0.00004303993,4.304287e-7,0.00001371845,0.001098449,0.9909362,0.00003362094,0.00006628643,0.0001033247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968407,0.00003135029,0.002693929,0.00007064909,0.00001544801,0.0001814953,0.0001029715,0.000006272303,0.0000572417],"genre_scores_gemma":[0.9985508,0.00006661163,0.0007964027,0.0001450488,0.0001543326,0.00002717031,0.0001891338,0.00001119966,0.00005927221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004548941,"threshold_uncertainty_score":0.3711937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736797684405293,"score_gpt":0.2235321360835027,"score_spread":0.1861641592394497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}