{"id":"W2034457721","doi":"10.1371/journal.pone.0097797","title":"Serum Stability and Physicochemical Characterization of a Novel Amphipathic Peptide C6M1 for SiRNA Delivery","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Small interfering RNA; Dynamic light scattering; Peptide; Circular dichroism; Chemistry; Biophysics; Random coil; Amphiphile; Nucleic acid; Gene knockdown; Oligonucleotide; RNA; Molecular biology; Biochemistry; RNase P; Förster resonance energy transfer; Fluorescence; Biology; Materials science; Gene; Nanotechnology; Nanoparticle; Copolymer; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003400869,0.0002184411,0.000133066,0.0002108933,0.0001941398,0.0002066192,0.0001597138,0.0002815456,0.000421592],"category_scores_gemma":[0.0006042084,0.00008462523,0.0001612901,0.0001324374,0.0001438881,0.0001271092,0.0001265569,0.0002726169,0.0002297848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000252338,"about_ca_system_score_gemma":0.0001731993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005028254,"about_ca_topic_score_gemma":0.0002788146,"domain_scores_codex":[0.9998831,0.00001680218,0.000008688006,0.0000213503,0.00005434827,0.00001575441],"domain_scores_gemma":[0.9997523,0.0000595284,0.00005609022,0.00001147343,0.00007841519,0.00004205196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005045769,0.00001130018,0.0001420576,0.00002275936,0.000002066829,0.0000281774,0.00001304328,0.0001185635,0.9984521,0.00002003672,0.00001984367,0.001119571],"study_design_scores_gemma":[0.000006443662,0.0001748437,0.001963079,0.000003770632,0.000005708795,0.0001432511,0.000008945618,0.001734527,0.9949811,0.00001519721,0.0009570532,0.000006108619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942539,0.001444373,0.003465901,0.00007365015,0.00001548158,0.00003750591,0.0001644025,0.00002290828,0.0005218731],"genre_scores_gemma":[0.9941907,0.0007227032,0.003862312,0.00005356641,0.00001054309,0.00004835433,0.0003543135,0.00001360395,0.0007438757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005028254,"threshold_uncertainty_score":0.001830816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736797684405293,"score_gpt":0.2235321360835027,"score_spread":0.1861641592394497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}