{"id":"W2034458673","doi":"10.1158/1535-7163.targ-11-b50","title":"Abstract B50: A phase I study of various administration schedules for RO4929097 (R) with multi-parameter assessment (pharmacokinetics [PK] and primary tumor xenograft [XG]) in patients (pts) with advanced solid cancers.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pharmacokinetics; Nausea; Vomiting; Dosing; Hypophosphatemia; Pharmacology; Cancer; Adverse effect; Internal medicine; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009921328,0.001449525,0.001395772,0.0005795711,0.0003712559,0.0008245973,0.0008650829,0.001182389,0.00508511],"category_scores_gemma":[0.0006381576,0.000642488,0.0009665079,0.0004412227,0.0009368968,0.000796883,0.0003303905,0.003020671,0.001881021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006502189,"about_ca_system_score_gemma":0.001016555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008815823,"about_ca_topic_score_gemma":0.001899353,"domain_scores_codex":[0.9997038,0.000113366,0.00001533396,0.00007222383,0.00003093242,0.00006420156],"domain_scores_gemma":[0.9995654,0.00006272078,0.00007792925,0.00005669631,0.00002210661,0.000215012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4146593,0.170275,0.006582004,0.001523091,0.001444325,0.0006337652,0.0006692867,0.006040358,0.2274469,0.0006953709,0.009547335,0.1604833],"study_design_scores_gemma":[0.1444369,0.8330373,0.01000765,0.00004174915,0.0002589771,0.0005327889,0.00007145336,0.001350346,0.006712791,0.000218126,0.003284174,0.00004778422],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989713,0.002123677,0.001176574,0.0003623113,0.00009088552,0.002542426,0.001512679,0.0001957836,0.002282778],"genre_scores_gemma":[0.98566,0.002114076,0.002575155,0.000735233,0.0000897854,0.002383492,0.002489751,0.00006591545,0.003886598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00508511,"threshold_uncertainty_score":0.0170114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02431198423476477,"score_gpt":0.3239793989035117,"score_spread":0.299667414668747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}