{"id":"W2034462829","doi":"10.1006/mthe.2001.0323","title":"Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors","year":2001,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Helper virus; Cre recombinase; Biology; Transgene; Vector (molecular biology); Viral vector; Cre-Lox recombination; Recombinase; Virus; Plasmid; Virology; Site-specific recombination; Cloning (programming); Computational biology; Genetics; Gene; Recombinant DNA; Recombination; Viral replication; Computer science; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009660868,0.000931135,0.0007581428,0.000997648,0.0003848605,0.000734303,0.0009789547,0.0007885428,0.002063102],"category_scores_gemma":[0.0004658285,0.0007617493,0.0006014073,0.0005041836,0.0003661268,0.0006117635,0.0005663583,0.002048395,0.003302254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004275483,"about_ca_system_score_gemma":0.0005608748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498679,"about_ca_topic_score_gemma":0.0004825148,"domain_scores_codex":[0.9992899,0.00008536039,0.0001013799,0.0002047564,0.0002367236,0.00008190425],"domain_scores_gemma":[0.9997126,0.00006643092,0.00005104279,0.00005684262,0.00005046814,0.00006260923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004209917,0.00004950815,0.00009618186,0.000157228,0.0000103028,0.0001021794,0.00004060539,0.0002505523,0.9887407,0.0005994782,0.0003264968,0.0095846],"study_design_scores_gemma":[0.00003710515,0.0003013222,0.0006106999,0.0000335744,0.00003850665,0.0007064185,0.0000189867,0.003101618,0.9597728,0.0001897438,0.03515653,0.00003266449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1383352,0.005585063,0.838517,0.0003700666,0.0005221591,0.002605464,0.003387444,0.004619885,0.006057862],"genre_scores_gemma":[0.3077952,0.006594279,0.6508169,0.0002886415,0.0001512721,0.001971958,0.01702726,0.0007285859,0.01462581],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002063102,"threshold_uncertainty_score":0.006901741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762609674777839,"score_gpt":0.2996024968009877,"score_spread":0.2719764000532093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}