{"id":"W2034462829","doi":"10.1006/mthe.2001.0323","title":"Development of a FLP/frt System for Generating Helper-Dependent Adenoviral Vectors","year":2001,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Helper virus; Cre recombinase; Biology; Transgene; Vector (molecular biology); Viral vector; Cre-Lox recombination; Recombinase; Virus; Plasmid; Virology; Site-specific recombination; Cloning (programming); Computational biology; Genetics; Gene; Recombinant DNA; Recombination; Viral replication; Computer science; Genetically modified mouse","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004856712,0.0002438287,0.0002458717,0.00009103549,0.0001481784,0.00003040557,0.0003571711,0.0001587086,0.00002185682],"category_scores_gemma":[0.00001941146,0.0002318403,0.0001716511,0.0001379786,0.00004899939,0.000003586657,0.00006886668,0.00008218827,0.000009857827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006344725,"about_ca_system_score_gemma":0.0002397319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007070179,"about_ca_topic_score_gemma":0.00004166981,"domain_scores_codex":[0.9982538,0.0001158126,0.0003925618,0.0004514941,0.0003490482,0.0004372321],"domain_scores_gemma":[0.9991115,0.00000958431,0.0001182445,0.0004850972,0.000172124,0.000103413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001609677,0.00009015272,0.00018561,0.00003907415,0.0002118171,0.00001113811,0.0001721829,0.0003240262,0.9733086,0.00002742229,0.00003403746,0.02398624],"study_design_scores_gemma":[0.00172058,0.001375421,0.00005115387,0.0000243771,0.000006940189,0.00001856484,0.0001600861,0.0002000702,0.9856234,0.000005444174,0.01055741,0.0002565905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731668,0.003638341,0.02216139,0.00004527979,0.0001210416,0.0006543773,0.00001240725,0.00002748095,0.0001729056],"genre_scores_gemma":[0.9914031,0.0001702495,0.007352868,0.0001874281,0.0001706256,0.000224167,0.0001066598,0.00007773423,0.0003071472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02372965,"threshold_uncertainty_score":0.9454172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762609674777839,"score_gpt":0.2996024968009877,"score_spread":0.2719764000532093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}