{"id":"W2034476880","doi":"10.1016/j.devcel.2011.06.010","title":"The Impact of Developmental Biology on Pluripotent Stem Cell Research: Successes and Challenges","year":2011,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Biology; Induced pluripotent stem cell; Developmental biology; Stem cell; Embryonic stem cell; Stem cell biology; Cell biology; Computational biology; Genetics; Gene; Embryogenesis; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008852948,0.0002498455,0.0001975847,0.0001388981,0.0003142214,0.00002590436,0.0005272217,0.0001722263,0.00004552432],"category_scores_gemma":[0.00002050107,0.0001699263,0.00008500788,0.0001499712,0.0004442616,0.0000074437,0.0006349806,0.0002226294,0.00007133766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001107633,"about_ca_system_score_gemma":0.0003829555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001702169,"about_ca_topic_score_gemma":0.00006442318,"domain_scores_codex":[0.9978951,0.0002723713,0.0003328677,0.0005290444,0.0003211763,0.0006493906],"domain_scores_gemma":[0.999207,0.0001044622,0.00009696748,0.000256598,0.0001546435,0.0001803031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006795659,0.0004907938,0.01095787,0.0001512642,0.0001564092,0.00002049213,0.001481076,0.000002368743,0.9644423,0.000146092,0.001211438,0.02026038],"study_design_scores_gemma":[0.0006208771,0.0009963578,0.01916257,0.00002083805,0.000003519763,0.00002539966,0.001986227,0.000004208744,0.9632523,0.00008084813,0.01360019,0.0002466393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9454437,0.0058838,0.00000644954,0.00005616026,0.00006471851,0.0003659553,0.0000239535,0.000009474425,0.04814577],"genre_scores_gemma":[0.9848215,0.01289081,0.0005729281,0.00001324361,0.00003128054,0.00004534163,0.000037205,0.00003230889,0.001555387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04659038,"threshold_uncertainty_score":0.6929394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1071336797156084,"score_gpt":0.3168999659728634,"score_spread":0.209766286257255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}