{"id":"W2034488904","doi":"10.1073/pnas.231473498","title":"Transgenic mice produced by retroviral transduction of male germ-line stem cells","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania","keywords":"Biology; Stem cell; Transgene; Embryonic stem cell; Cell biology; Transduction (biophysics); Haematopoiesis; Germline; Viral vector; Germ cell; Adult stem cell; Genetic enhancement; Cell culture; Gene delivery; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005693281,0.00007617856,0.0001022587,0.00004802534,0.00007378716,0.000005317965,0.0003236353,0.00009180736,0.000006662772],"category_scores_gemma":[0.0000259845,0.00005487442,0.0000813866,0.0003126616,0.0004028661,0.00001599263,0.00002735321,0.00006859171,3.011851e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006846063,"about_ca_system_score_gemma":0.00002349673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003158784,"about_ca_topic_score_gemma":4.881682e-8,"domain_scores_codex":[0.9989023,0.000005927128,0.0002667629,0.0002832936,0.0004369448,0.0001048276],"domain_scores_gemma":[0.9995101,0.00000429733,0.0002716707,0.00001186179,0.0001822371,0.00001984157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005621583,0.00005312566,0.0009920553,0.00003541721,0.00001337312,7.175786e-10,0.00003918319,0.00008386908,0.9975532,0.0001860762,0.0005662725,0.000421179],"study_design_scores_gemma":[0.000129517,0.0002201153,0.002053849,0.00001437378,0.0000140462,0.000008832181,0.00007147441,0.00006992764,0.9956384,0.0002634875,0.001454018,0.0000619405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997809,0.0004776961,0.000009912747,0.0009816313,0.00003955509,0.0001456208,0.00001426729,0.00000246041,0.0005198367],"genre_scores_gemma":[0.9979809,0.0003514677,0.0002770376,0.00003793568,0.0001767004,0.000003543334,4.896733e-7,0.000004450027,0.001167474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001914813,"threshold_uncertainty_score":0.2237714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628508385934468,"score_gpt":0.2716399567607816,"score_spread":0.2453548729014369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}