{"id":"W2034488904","doi":"10.1073/pnas.231473498","title":"Transgenic mice produced by retroviral transduction of male germ-line stem cells","year":2001,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":305,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institutes of Health; Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania","keywords":"Biology; Stem cell; Transgene; Embryonic stem cell; Cell biology; Transduction (biophysics); Haematopoiesis; Germline; Viral vector; Germ cell; Adult stem cell; Genetic enhancement; Cell culture; Gene delivery; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004803897,0.0007290401,0.0004720479,0.0008003516,0.0002933186,0.000437542,0.000754029,0.0009826832,0.005003467],"category_scores_gemma":[0.0001970893,0.0005758223,0.0004647625,0.0003835049,0.0004405137,0.0003582573,0.0003681868,0.001718005,0.002881581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905412,"about_ca_system_score_gemma":0.0003069034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002878612,"about_ca_topic_score_gemma":0.0004647258,"domain_scores_codex":[0.9996606,0.00004294626,0.00004312709,0.00008817918,0.0001034024,0.00006167039],"domain_scores_gemma":[0.9996789,0.00003917517,0.0001141664,0.00004257464,0.00002364317,0.0001017122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095201,0.0001043083,0.0001773454,0.00004799341,0.00001674275,0.000130209,0.00003656227,0.00004873279,0.9953321,0.0007911422,0.0003010393,0.002904354],"study_design_scores_gemma":[0.0003248001,0.001100881,0.004014933,0.00005323197,0.0001289155,0.002175575,0.00004621029,0.001107956,0.945483,0.0006275654,0.04490902,0.0000278125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8512187,0.00510274,0.1115891,0.0009725667,0.001218778,0.00135117,0.006745789,0.005289264,0.01651194],"genre_scores_gemma":[0.833882,0.008839508,0.06698207,0.0008522882,0.0002858028,0.001809131,0.01414909,0.0008903889,0.07230967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005003467,"threshold_uncertainty_score":0.01673824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628508385934468,"score_gpt":0.2716399567607816,"score_spread":0.2453548729014369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}