{"id":"W2034532011","doi":"10.1074/jbc.m114.594812","title":"p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Prohibitin; Apoptosis; mitochondrial fusion; Biology; VDAC1; Mitochondrion; Cisplatin; DNA fragmentation; Fragmentation (computing); Molecular biology; Cell biology; Mitochondrial fission; MFN2; Mitochondrial DNA; Cancer research; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005201006,0.0002822959,0.0004915717,0.00002891041,0.000150414,0.00002868527,0.0006538752,0.0006632683,0.0001653772],"category_scores_gemma":[0.001909439,0.0001485774,0.0004009176,0.0001868921,0.0002522886,0.00001186865,0.0001479098,0.0004125489,0.000001409674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000610858,"about_ca_system_score_gemma":0.0002459357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001309655,"about_ca_topic_score_gemma":0.00001153737,"domain_scores_codex":[0.9979076,0.0002671292,0.0007862521,0.0004091354,0.0002779966,0.0003519088],"domain_scores_gemma":[0.9980965,0.0001676861,0.001014074,0.000356099,0.0002529364,0.0001126535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001129333,0.00008664129,0.0003336792,0.00004392406,0.00004539366,0.000002147181,0.00007093263,0.000009420387,0.992813,0.000001743341,0.00391719,0.001546596],"study_design_scores_gemma":[0.002558444,0.0007359131,0.0001718677,0.00006977504,0.00004719001,0.0000538877,0.0001321962,0.00007487694,0.9756865,0.0002098089,0.02005936,0.0002002032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955513,0.0004099815,0.001070749,0.00128156,0.000745672,0.0006139668,0.00006554007,0.00000645044,0.0002548207],"genre_scores_gemma":[0.9953123,0.00005720609,0.001751067,0.001064092,0.001109911,0.00007341643,0.00004963492,0.00001987612,0.0005625321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01712652,"threshold_uncertainty_score":0.6058812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671663926165262,"score_gpt":0.2632770751260516,"score_spread":0.236560435864399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}