{"id":"W2034532011","doi":"10.1074/jbc.m114.594812","title":"p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Prohibitin; Apoptosis; mitochondrial fusion; Biology; VDAC1; Mitochondrion; Cisplatin; DNA fragmentation; Fragmentation (computing); Molecular biology; Cell biology; Mitochondrial fission; MFN2; Mitochondrial DNA; Cancer research; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000082379,0.0002298019,0.0002253955,0.000211522,0.0002378046,0.0002393012,0.0001375529,0.0002952134,0.001309514],"category_scores_gemma":[0.0001692283,0.0001556308,0.0002958448,0.0001478537,0.0002231488,0.0001914267,0.0001919054,0.0003929915,0.0004928241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003440249,"about_ca_system_score_gemma":0.0001995879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006593085,"about_ca_topic_score_gemma":0.0005758961,"domain_scores_codex":[0.9999073,0.00001193089,0.00001329317,0.00002354434,0.00002129914,0.00002256789],"domain_scores_gemma":[0.9998459,0.00001892688,0.00006217722,0.00001802879,0.00001302525,0.00004199601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001296911,0.00002311979,0.0004539394,0.00003012744,0.000004649121,0.0002032173,0.00001599137,0.00003567294,0.9982975,0.00007365399,0.00005775861,0.0006746394],"study_design_scores_gemma":[0.00005817436,0.0002774076,0.04263975,0.00001829651,0.00004007178,0.002051153,0.00009092475,0.001883123,0.9493323,0.000164987,0.003432787,0.00001099599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972687,0.001032908,0.0007675423,0.0001153311,0.00002179763,0.0000120092,0.0002620481,0.00004875856,0.0004708493],"genre_scores_gemma":[0.9983255,0.0002987167,0.0003069834,0.00002879175,0.00000321752,0.0000184088,0.0003739583,0.000009414704,0.0006348614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309514,"threshold_uncertainty_score":0.004380763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671663926165262,"score_gpt":0.2632770751260516,"score_spread":0.236560435864399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}