{"id":"W2034545959","doi":"10.1016/j.reprotox.2011.05.020","title":"Valproic acid-induced DNA damage increases embryonic p27KIP1 and caspase-3 expression: A mechanism for valproic-acid induced neural tube defects","year":2011,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Valproic Acid; Apoptosis; Neural tube; Caspase 3; DNA damage; Cell cycle; Blot; Immunohistochemistry; Molecular biology; Chemistry; Andrology; Teratology; Biology; Programmed cell death; Embryo; DNA; Cell biology; Biochemistry; Fetus; Medicine; Immunology; Genetics; Pregnancy; Epilepsy; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576386,0.0006769493,0.0003061704,0.0005910086,0.0002593602,0.0003735712,0.0003330599,0.0004483417,0.001548176],"category_scores_gemma":[0.0002064849,0.0003259009,0.0004112259,0.0001922827,0.0003713566,0.0004258777,0.0003284292,0.0006612165,0.0002215317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007102733,"about_ca_system_score_gemma":0.0003819633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00104597,"about_ca_topic_score_gemma":0.0014945,"domain_scores_codex":[0.9998049,0.0000370274,0.00002753042,0.00005114876,0.00004758998,0.00003179602],"domain_scores_gemma":[0.9998119,0.00002080527,0.00008025197,0.00003147776,0.00002072424,0.00003479369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002989447,0.00001367116,0.0003736016,0.00003228973,0.00001351559,0.0001918622,0.00001571215,0.00007775952,0.997548,0.0002019446,0.00003511149,0.001197502],"study_design_scores_gemma":[0.00001535027,0.0001180333,0.004225028,0.000004241695,0.00001347427,0.0003293828,0.00002497144,0.0002852105,0.9942552,0.00008586338,0.0006396392,0.00000348768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865152,0.004587428,0.005945091,0.0003972101,0.00007158155,0.00004457912,0.0007190168,0.0002297324,0.001490094],"genre_scores_gemma":[0.9936243,0.001483,0.001836554,0.00005117276,0.000008588237,0.00003633935,0.0002968225,0.00002464609,0.002638476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548176,"threshold_uncertainty_score":0.005179167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04346107405196058,"score_gpt":0.2802711209401108,"score_spread":0.2368100468881502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}