{"id":"W2034563844","doi":"10.1074/jbc.m702615200","title":"Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Proteases; Serine; Enzyme; Chemistry; Biochemistry; Cathepsin; Cathepsin C; Enzyme activator; Enzyme inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003085689,0.000457095,0.0005546155,0.0001339087,0.0001080719,0.0004626384,0.0003972265,0.0004527064,0.0009263544],"category_scores_gemma":[0.0001973551,0.000139656,0.0004309145,0.0001894831,0.0002240392,0.0002578559,0.0001806708,0.0009260412,0.0003416157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164287,"about_ca_system_score_gemma":0.0003555026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005523568,"about_ca_topic_score_gemma":0.000912819,"domain_scores_codex":[0.9996518,0.00004278905,0.00003743906,0.00006718963,0.0001182933,0.00008253574],"domain_scores_gemma":[0.999867,0.00003451232,0.00004057627,0.00002363119,0.0000159407,0.00001840084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008534418,0.00004750966,0.00005003226,0.00004500673,0.000009669356,0.00003146945,0.000005545151,0.00005251603,0.9985696,0.00005100213,0.000027499,0.001024825],"study_design_scores_gemma":[0.000007798734,0.0003122278,0.0006855701,0.000003927963,0.00001314007,0.0001190207,0.000004317035,0.0003021579,0.9976053,0.000009122654,0.0009352277,0.000002150906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718162,0.01156545,0.01322369,0.0001854415,0.00008433965,0.0001409623,0.000451925,0.0001495322,0.002382399],"genre_scores_gemma":[0.9896023,0.002811434,0.005163314,0.00007357746,0.00001929606,0.00008707103,0.0004127721,0.00001559551,0.001814597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009263544,"threshold_uncertainty_score":0.003098905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398392173064733,"score_gpt":0.2458183309980744,"score_spread":0.2318344092674271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}