{"id":"W2034586537","doi":"10.1101/gad.1985910","title":"The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism","year":2010,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":366,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; National Cancer Institute; Damon Runyon Cancer Research Foundation","keywords":"Glutamine; Biology; Citric acid cycle; Metabolism; Biochemistry; Carbohydrate metabolism; Signal transduction; Glucose uptake; Growth factor; Cell growth; Receptor; Endocrinology; Amino acid; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003565532,0.0003752725,0.0002905859,0.00007572764,0.0003801878,0.0000904983,0.0005465847,0.0002009398,0.00004382216],"category_scores_gemma":[0.0001566499,0.0002760244,0.0001245316,0.0001896001,0.00007762381,0.000006020689,0.000303884,0.0001701513,0.00007951695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002159139,"about_ca_system_score_gemma":0.0004580109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004103835,"about_ca_topic_score_gemma":0.001146621,"domain_scores_codex":[0.9979497,0.00004091764,0.0004397992,0.0006006699,0.0003410347,0.0006279194],"domain_scores_gemma":[0.9986943,0.00002547756,0.0001141787,0.0006438795,0.0002267866,0.0002953491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004126539,0.00004071775,0.000113527,0.00000623291,0.00006813992,9.349962e-7,0.0001424187,0.000001126182,0.7415726,0.0001369436,0.0004079924,0.2574681],"study_design_scores_gemma":[0.0002453072,0.00002537715,0.01837838,0.000003328015,0.00001146644,0.00001220297,0.00003842697,0.00000145376,0.4817742,0.00001411525,0.4992723,0.0002233804],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862382,0.00809739,0.0002865808,0.0003797852,0.004280544,0.0004424234,0.00004274354,0.00004344152,0.0001888386],"genre_scores_gemma":[0.987534,0.00387539,0.004253682,0.0005770366,0.002082004,0.0001960196,0.0001034933,0.00006855126,0.001309761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4988643,"threshold_uncertainty_score":0.9999692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112991070533676,"score_gpt":0.2300199733178729,"score_spread":0.2187208662645053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}