{"id":"W2034595206","doi":"10.1002/ijc.20830","title":"Tissue inhibitor of metalloproteinase‐3 (<i>TIMP‐3</i>) gene is methylated in the development of esophageal adenocarcinoma: Loss of expression correlates with poor prognosis","year":2005,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Methylation; Tissue inhibitor of metalloproteinase; Biology; Adenocarcinoma; Cancer research; TIMP1; Pathology; DNA methylation; Cell culture; Immunohistochemistry; Metastasis; Gene expression; Extracellular matrix; Gene; Cancer; Medicine; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835583,0.0001135722,0.0002106129,0.0001352586,0.00001401893,0.000006177782,0.0003007252,0.00009817611,0.0000518713],"category_scores_gemma":[0.00002281322,0.00007826403,0.00007864053,0.0001271641,0.00007610794,0.00001837294,0.0000475943,0.0001076253,2.999214e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006794059,"about_ca_system_score_gemma":0.0003140112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003085612,"about_ca_topic_score_gemma":0.00009531518,"domain_scores_codex":[0.9985119,0.00005256645,0.0006870953,0.0001253193,0.0005283449,0.0000947494],"domain_scores_gemma":[0.9983617,0.00001785671,0.0008279628,0.0000942226,0.0006694674,0.00002875976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009032834,0.0001647728,0.01309981,0.00002373266,0.0004067427,0.000006248848,0.0009363727,0.003746249,0.9636896,0.000004140983,0.0001449586,0.0168741],"study_design_scores_gemma":[0.001301209,0.0002304387,0.01819362,0.0002104479,0.00005603034,0.00004360834,0.00006190791,0.00007159029,0.978908,0.00001420673,0.0008342713,0.00007463736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903863,0.007712619,0.001094758,0.0004505642,0.0001375724,0.0001725556,0.00002299783,9.68153e-7,0.00002163967],"genre_scores_gemma":[0.994241,0.0001854067,0.005235017,0.00003848623,0.0002216179,0.000015321,0.00001456964,0.0000124444,0.00003611458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01679947,"threshold_uncertainty_score":0.3191514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007978551001852772,"score_gpt":0.2769381794071841,"score_spread":0.2689596284053313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}