{"id":"W2034619626","doi":"10.1038/nchembio.1157","title":"Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chromatin; Repressor; Fusion protein; Function (biology); Biology; Genetics; Cell biology; Biochemistry; DNA; Chemistry; Gene; Transcription factor; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006421069,0.0004864851,0.0002517502,0.0002576981,0.0005476074,0.0004586304,0.001208671,0.001408601,0.004044273],"category_scores_gemma":[0.0007235801,0.0003440756,0.0003338795,0.000226744,0.0005910554,0.0003866046,0.0007280993,0.001823377,0.001133747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00116906,"about_ca_system_score_gemma":0.0007043207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128769,"about_ca_topic_score_gemma":0.002521393,"domain_scores_codex":[0.9997646,0.0000472595,0.00000595451,0.00005860588,0.0000571157,0.00006651209],"domain_scores_gemma":[0.9997032,0.0001020152,0.00005147355,0.00003828489,0.00004162294,0.00006331216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190008,0.00005048944,0.0001855033,0.00005812047,0.00001102562,0.000114664,0.00003296668,0.000240859,0.9927567,0.001849486,0.0005280959,0.004053197],"study_design_scores_gemma":[0.0000323698,0.0001070583,0.0002807708,0.000004219433,0.000006914232,0.0001058304,0.00001653742,0.0009216783,0.9927394,0.0002326599,0.005543881,0.000008725076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7784703,0.003446754,0.1845703,0.005244778,0.0004585282,0.0002982302,0.001677705,0.001107153,0.02472619],"genre_scores_gemma":[0.9438746,0.0009868111,0.0400508,0.001091833,0.00004909793,0.0001667968,0.001216416,0.0001221199,0.0124415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004044273,"threshold_uncertainty_score":0.01352942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007598735419361634,"score_gpt":0.2716551021003879,"score_spread":0.2640563666810263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}