{"id":"W2034619626","doi":"10.1038/nchembio.1157","title":"Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain","year":2013,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":171,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Chromatin; Repressor; Fusion protein; Function (biology); Biology; Genetics; Cell biology; Biochemistry; DNA; Chemistry; Gene; Transcription factor; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043703,0.0001643699,0.0002183696,0.00002249749,0.0000283299,0.0000138247,0.000300802,0.0008028236,0.00001572447],"category_scores_gemma":[0.0004687746,0.0001031237,0.0001715491,0.00009446152,0.0002444783,0.000004231716,0.0001286237,0.0002600159,0.000003079344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001086753,"about_ca_system_score_gemma":0.00003835736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001252564,"about_ca_topic_score_gemma":0.000001291356,"domain_scores_codex":[0.9989897,0.0000429992,0.0002697567,0.0003625877,0.00007586634,0.0002590981],"domain_scores_gemma":[0.999112,0.0001752204,0.0001199068,0.0003677336,0.0001803709,0.00004477491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007446275,0.00004835942,0.0004138458,0.00001837165,0.00006983981,6.151721e-8,0.00001414869,5.245111e-7,0.9943119,0.001330496,0.0008554638,0.002862584],"study_design_scores_gemma":[0.0004448858,0.0001056848,0.0002236187,0.000005153294,0.00002624626,0.000001716278,0.00001699422,0.00002203031,0.9741754,0.009573529,0.01526987,0.0001349001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759436,0.006923507,0.01428472,0.001773838,0.0001704733,0.0005802026,0.00005082272,0.000009118553,0.0002636881],"genre_scores_gemma":[0.9903151,0.0001249075,0.00805794,0.0003591805,0.0004538907,0.000150157,0.0003994981,0.00001935934,0.0001199305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02013647,"threshold_uncertainty_score":0.6192111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007598735419361634,"score_gpt":0.2716551021003879,"score_spread":0.2640563666810263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}