{"id":"W2034633743","doi":"10.1371/journal.pone.0112671","title":"Cell Fate Decisions in Malignant Hematopoiesis: Leukemia Phenotype Is Determined by Distinct Functional Domains of the MN1 Oncogene","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; BC Cancer Agency; University of British Columbia","funders":"Deutsche Krebshilfe; José Carreras Leukämie-Stiftung; Bundesministerium für Bildung und Forschung; Leuka; University of British Columbia; Kay Kendall Leukaemia Fund; Hector Stiftung; Stem Cell Network; Terry Fox Foundation; Deutsche Forschungsgemeinschaft; BC Cancer Agency; European Hematology Association; Child and Family Research Institute; Cancer Research Society","keywords":"Biology; Phenotype; Oncogene; Myeloid; Myeloid leukemia; Haematopoiesis; Cancer research; Leukemia; Cellular differentiation; Cell; Genetics; Gene; Stem cell; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267564,0.0002536962,0.0001307995,0.0002603199,0.000167927,0.0002931824,0.0001264201,0.0001965899,0.0005724374],"category_scores_gemma":[0.0001324684,0.0001051696,0.0001065213,0.0001193413,0.0004012281,0.0002167903,0.0003024943,0.0003398556,0.0002238953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003626941,"about_ca_system_score_gemma":0.0001770685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003871595,"about_ca_topic_score_gemma":0.0005907839,"domain_scores_codex":[0.9998767,0.00002047468,0.00001120218,0.00002700662,0.0000327863,0.00003177575],"domain_scores_gemma":[0.9998945,0.00002565601,0.00003324158,0.00001203195,0.000007211009,0.00002742761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007593243,0.000008574883,0.0004572478,0.00001050923,7.226104e-7,0.00002286579,0.00001433669,0.00005135998,0.9986759,0.0001435546,0.000004265921,0.0005347186],"study_design_scores_gemma":[0.000008906774,0.0001500067,0.01596139,0.000005346173,0.000009348028,0.0005726274,0.00004397527,0.0009651663,0.9807088,0.00012572,0.001443332,0.000005364145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979145,0.0005107901,0.001021887,0.00002233596,0.000002174328,0.000004703644,0.00009284169,0.00001873447,0.000411912],"genre_scores_gemma":[0.9983087,0.0002828884,0.0007217976,0.00001007482,0.000001252862,0.000007568928,0.0001546352,0.000008329371,0.0005047304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005724374,"threshold_uncertainty_score":0.002631545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03790517298169907,"score_gpt":0.2523687331641194,"score_spread":0.2144635601824203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}