{"id":"W2034649150","doi":"10.1371/journal.pone.0013927","title":"Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Public Health Agency; Directorate for Biological Sciences; University Grants Committee; Public Health Agency of Canada; Biogen","keywords":"Biology; Interferon; STAT1; STAT2; Influenza A virus; Viral replication; Signal transduction; Virology; Interferon-stimulated gene; Tyrosine phosphorylation; Influenza A virus subtype H5N1; Virus; Cell biology; Immune system; Innate immune system; STAT3; STAT protein; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001056361,0.000189014,0.0003221044,0.000125418,0.0001206878,0.00005067889,0.0001158739,0.0001146078,0.001684054],"category_scores_gemma":[0.0001999159,0.0001605365,0.0001075314,0.0001365436,0.00007046515,0.000160536,0.00005909289,0.0007848198,0.0002655373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004170131,"about_ca_system_score_gemma":0.00006191376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001309192,"about_ca_topic_score_gemma":0.00005493364,"domain_scores_codex":[0.9987713,0.00001621323,0.0003312295,0.0002800833,0.0003184936,0.0002827087],"domain_scores_gemma":[0.9991336,0.00003812062,0.0001040343,0.0003664424,0.0001755207,0.0001822203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002318977,0.0004283008,0.002273018,0.000104773,0.0001530666,0.00001656601,0.0003247123,0.000001740217,0.9957117,0.00008633178,0.00006771187,0.0006001962],"study_design_scores_gemma":[0.0008104598,0.0005617847,0.002575551,0.0006025375,0.0001598075,0.00002433412,0.00004660143,0.0009897759,0.9932077,0.0001165534,0.0007168732,0.000188016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967313,0.00003079225,0.00006111701,0.0003681188,0.0001685133,0.0005741736,0.00002219839,0.0001317333,0.001912011],"genre_scores_gemma":[0.9944744,0.000001579399,0.003630513,0.0004526868,0.0007187313,0.00007193875,0.00002627143,0.00004205468,0.0005818988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003569396,"threshold_uncertainty_score":0.9992285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04847998114751358,"score_gpt":0.2875384993500907,"score_spread":0.2390585182025772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}