{"id":"W2034649150","doi":"10.1371/journal.pone.0013927","title":"Influenza Virus Non-Structural Protein 1 (NS1) Disrupts Interferon Signaling","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Public Health Agency; Directorate for Biological Sciences; University Grants Committee; Public Health Agency of Canada; Biogen","keywords":"Biology; Interferon; STAT1; STAT2; Influenza A virus; Viral replication; Signal transduction; Virology; Interferon-stimulated gene; Tyrosine phosphorylation; Influenza A virus subtype H5N1; Virus; Cell biology; Immune system; Innate immune system; STAT3; STAT protein; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009903622,0.0003031537,0.0001931049,0.0001203197,0.0001384427,0.0001833706,0.0001126142,0.0002257859,0.0009501269],"category_scores_gemma":[0.00005025468,0.0001016913,0.0002278121,0.00008115818,0.0001871577,0.00009621667,0.0001093877,0.0003890933,0.0002700362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003516913,"about_ca_system_score_gemma":0.000187314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969734,"about_ca_topic_score_gemma":0.0007865326,"domain_scores_codex":[0.9998945,0.00001842432,0.0000114781,0.00002032083,0.00002735645,0.00002792145],"domain_scores_gemma":[0.9999584,0.000008038295,0.00001456124,0.00000497418,0.000003553297,0.00001053016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006709361,0.00001472556,0.00009120963,0.00002817494,0.000003408744,0.00001635345,0.000004605116,0.00003846261,0.9991202,0.00005958694,0.00003026558,0.0005258978],"study_design_scores_gemma":[0.000009215584,0.0002480204,0.003213482,0.000005485513,0.00000962083,0.0001392576,0.00001455278,0.0005671131,0.9932741,0.00003950436,0.002476912,0.000002746563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99245,0.00282679,0.002086537,0.000131576,0.00007495034,0.00002962612,0.0007396942,0.00008618213,0.001574657],"genre_scores_gemma":[0.9953506,0.001352219,0.001302738,0.00005307143,0.000009426461,0.00002268886,0.0005609908,0.00001141884,0.001336915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009501269,"threshold_uncertainty_score":0.003178477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04847998114751358,"score_gpt":0.2875384993500907,"score_spread":0.2390585182025772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}