{"id":"W2034661714","doi":"10.1021/jm401507s","title":"Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Simeprevir; Ribavirin; NS3; Hepatitis C virus; Pharmacology; Pegylated interferon; Virology; Sofosbuvir; Tolerability; Protease inhibitor (pharmacology); Protease; Hepatitis C; Daclatasvir; Medicine; Chemistry; Virus; Viral load; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002771637,0.0003164013,0.0002159787,0.0003658067,0.0001094972,0.0002551426,0.0001898336,0.0001774183,0.0008111816],"category_scores_gemma":[0.0001156947,0.0001289562,0.0002643908,0.0001563369,0.0001481164,0.0002221123,0.0002089486,0.0003601208,0.0003115875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280326,"about_ca_system_score_gemma":0.0003213688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003894906,"about_ca_topic_score_gemma":0.0008766318,"domain_scores_codex":[0.9999338,0.00001396188,0.00000482872,0.00001268548,0.00002241288,0.0000121631],"domain_scores_gemma":[0.999971,0.000002690157,0.000004891765,0.000002259854,0.000007124213,0.00001202645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004767351,0.0003499443,0.0005773106,0.0003575302,0.00004567452,0.0004993561,0.00006331435,0.002853019,0.8611114,0.002815395,0.001612233,0.1292381],"study_design_scores_gemma":[0.0005868764,0.01076401,0.004210773,0.00006976588,0.0001031591,0.001581133,0.00003837993,0.006314034,0.8946507,0.0006289507,0.08101923,0.00003296305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8467048,0.06576511,0.05024419,0.001832479,0.0003741329,0.001113472,0.002052154,0.0005747678,0.03133874],"genre_scores_gemma":[0.9280722,0.03785762,0.02555341,0.0005444866,0.00007646543,0.0001479884,0.00128341,0.00002859897,0.006435852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008111816,"threshold_uncertainty_score":0.00271368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02035886182329065,"score_gpt":0.303705112231439,"score_spread":0.2833462504081484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}