{"id":"W2034666741","doi":"10.1016/j.yexcr.2010.01.018","title":"Epigenetic changes to human umbilical cord blood cells cultured with three proteins indicate partial reprogramming to a pluripotent state","year":2010,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Biology; Reprogramming; Homeobox protein NANOG; Cell biology; Stem cell; Cell potency; DNA methylation; Induced pluripotent stem cell; Embryonic stem cell; Molecular biology; Cellular differentiation; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001143768,0.00037712,0.0002972959,0.0002777583,0.0005439111,0.0002424961,0.001002171,0.0002325149,0.0001917742],"category_scores_gemma":[0.00005751496,0.0003233486,0.00009734724,0.0005704984,0.000388929,0.000008527553,0.001320265,0.000808247,0.000381619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007008999,"about_ca_system_score_gemma":0.0001909325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005344222,"about_ca_topic_score_gemma":0.001903338,"domain_scores_codex":[0.9948424,0.0002657477,0.0003401772,0.001460018,0.001494093,0.00159764],"domain_scores_gemma":[0.9972799,0.00002468157,0.00006837476,0.00120627,0.0002906325,0.001130187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009010046,0.0009980537,0.0005204949,0.00004021709,0.00005612953,0.0001018352,0.000602438,0.00002007668,0.9939672,0.000008912511,0.001143186,0.001640414],"study_design_scores_gemma":[0.001074266,0.006319235,0.0003849367,0.00002482833,0.000007922215,0.00001955254,0.0003120085,0.00001211513,0.9579427,0.000008838398,0.03347977,0.0004138415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941563,0.0002972078,0.0002333028,0.0005711711,0.0001011789,0.003597661,0.0000284675,0.00004234826,0.0009723771],"genre_scores_gemma":[0.9892403,0.00001984508,0.004465122,0.0001339943,0.0003631309,0.00179163,0.00007585924,0.0001041136,0.003805995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03602455,"threshold_uncertainty_score":0.9999219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0365546027579821,"score_gpt":0.3518848495143804,"score_spread":0.3153302467563983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}