{"id":"W2034666763","doi":"10.1002/art.21535","title":"Collagen and proteoglycan turnover in focally damaged human ankle cartilage: Evidence for a generalized response and active matrix remodeling across the entire joint surface","year":2005,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada; Montreal Children's Hospital; Jewish General Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging","keywords":"Cartilage; Lesion; Aggrecan; Type II collagen; Proteoglycan; Cartilage oligomeric matrix protein; Extracellular matrix; Osteoarthritis; Pathology; Glycosaminoglycan; Anatomy; Chemistry; Biology; Medicine; Cell biology; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450087,0.0002069848,0.0002145563,0.0004226966,0.0001395029,0.0002003095,0.0001419593,0.0003747253,0.001294959],"category_scores_gemma":[0.0002055295,0.0001891059,0.0001579863,0.0001856912,0.0002900145,0.0001775942,0.0001980361,0.000186069,0.0002680386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462956,"about_ca_system_score_gemma":0.0001183522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009450201,"about_ca_topic_score_gemma":0.0009200707,"domain_scores_codex":[0.9998498,0.00001890567,0.00001327762,0.00003935443,0.00005134587,0.00002737464],"domain_scores_gemma":[0.9997559,0.00001695194,0.00009324144,0.00003006217,0.00004015366,0.00006373527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003278593,0.000018262,0.003357148,0.00004866431,0.00001205477,0.0001920164,0.00003516818,0.00001774337,0.9952528,0.000005436385,0.000009697284,0.0007230891],"study_design_scores_gemma":[0.00006339195,0.001780756,0.6610594,0.00001993221,0.00008216126,0.006010742,0.000446817,0.0006913437,0.3289691,0.00005598686,0.0008046138,0.00001576266],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998592,0.0008706484,0.0002812812,0.000008527404,0.000002479085,0.000008251253,0.00005641769,0.000007615785,0.0001726847],"genre_scores_gemma":[0.9987753,0.0002491442,0.0003050088,0.00001939317,0.00000638702,0.00001559675,0.0001191878,0.000002299138,0.0005075353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294959,"threshold_uncertainty_score":0.004332125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03761360807986117,"score_gpt":0.3313185941317961,"score_spread":0.2937049860519349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}