{"id":"W2034666807","doi":"10.1021/bi010445f","title":"Thermodynamic Analysis of the Binding of Aromatic Hydroxamic Acid Analogues to Ferric Horseradish Peroxidase","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"","keywords":"Chemistry; Isothermal titration calorimetry; Ferric; Horseradish peroxidase; Enthalpy; Heme; Peroxidase; Hydroxamic acid; Stereochemistry; Binding site; Titration; Crystallography; Inorganic chemistry; Organic chemistry; Physical chemistry; Enzyme; Biochemistry; Thermodynamics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004589195,0.0003392019,0.0004975781,0.0002564657,0.000288713,0.0003789891,0.0004832925,0.0002245268,0.001348059],"category_scores_gemma":[0.001254774,0.0002196606,0.0002655215,0.0002535071,0.0003297803,0.0002980559,0.0002413989,0.0005860178,0.0003059186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006422658,"about_ca_system_score_gemma":0.0002790779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001788413,"about_ca_topic_score_gemma":0.001640489,"domain_scores_codex":[0.9996986,0.00007147617,0.00001360192,0.00005279321,0.0001197217,0.00004377634],"domain_scores_gemma":[0.999621,0.000179429,0.00004812884,0.00001494316,0.00008042312,0.0000560007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005883899,0.000203462,0.007185347,0.0002797445,0.0001220451,0.000100762,0.0001256611,0.02084965,0.9591188,0.001714962,0.0003095075,0.009401767],"study_design_scores_gemma":[0.00004004571,0.001183333,0.03429852,0.00001383307,0.00006998771,0.0002278803,0.0001282597,0.2226108,0.7373533,0.000941988,0.003055147,0.00007680059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928102,0.0009563614,0.004766846,0.00004579196,0.00001424917,0.00002535523,0.0001572677,0.00004094716,0.001182987],"genre_scores_gemma":[0.9975061,0.0003875339,0.001289136,0.00001168647,0.0000074519,0.00002799869,0.0003079645,0.000010776,0.0004514301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788413,"threshold_uncertainty_score":0.00466001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00828813970999518,"score_gpt":0.249974551676302,"score_spread":0.2416864119663069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}