{"id":"W2034674750","doi":"10.1007/s00412-012-0373-x","title":"HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction","year":2012,"lang":"en","type":"article","venue":"Chromosoma","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Connaught Fund; University of Toronto","keywords":"Telomerase; Telomere; Biology; Telomerase RNA component; Telomerase reverse transcriptase; Molecular biology; Protein subunit; HMGB1; Cell biology; Ribonucleoprotein; Gene knockout; Gene; RNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357035,0.0004566218,0.0003468657,0.0008675775,0.0002353137,0.0003495729,0.0002793419,0.0005382356,0.003121161],"category_scores_gemma":[0.0001450794,0.0003034382,0.0003514853,0.000287154,0.0003899323,0.0001750844,0.000265438,0.0007007996,0.0007442918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002220758,"about_ca_system_score_gemma":0.0002671579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006926202,"about_ca_topic_score_gemma":0.001200745,"domain_scores_codex":[0.9998333,0.00002174629,0.00002632274,0.00003564838,0.00005394919,0.00002890641],"domain_scores_gemma":[0.9996659,0.00004264186,0.0001199363,0.00003652622,0.0000164582,0.0001186627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162401,0.00001358548,0.0002075174,0.00001995048,0.00001054228,0.0001264308,0.00001256578,0.00002960691,0.998499,0.000195047,0.00003788978,0.0006854194],"study_design_scores_gemma":[0.00004233462,0.0001217286,0.005454063,0.00001154157,0.00004854017,0.0007594039,0.00004493121,0.0003665252,0.9910122,0.0001425462,0.001988127,0.00000814055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898444,0.0023351,0.00415279,0.0002001112,0.00007354747,0.00002013451,0.001236059,0.0003665191,0.001771245],"genre_scores_gemma":[0.9881529,0.001016472,0.002163968,0.000065227,0.00001672454,0.0000319016,0.0007105464,0.00008434114,0.007757872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003121161,"threshold_uncertainty_score":0.01044136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940079215985285,"score_gpt":0.2622445202306351,"score_spread":0.2428437280707822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}