{"id":"W2034687379","doi":"10.1074/jbc.m111.229294","title":"A Conserved Residue in the Yeast Bem1p SH3 Domain Maintains the High Level of Binding Specificity Required for Function","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Computational biology; Yeast; SH3 domain; Function (biology); Residue (chemistry); Binding site; Biology; Consensus sequence; Biochemistry; Conserved sequence; Plasma protein binding; Sequence (biology); Binding domain; Protein function; Binding selectivity; Peptide sequence; Genetics; Gene; Proto-oncogene tyrosine-protein kinase Src; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652647,0.0002979286,0.0004013222,0.0001487213,0.0002604912,0.0002737465,0.0002706613,0.0003449112,0.0008101641],"category_scores_gemma":[0.0002479328,0.0001749544,0.00021515,0.0001318759,0.000399187,0.0001709851,0.0002717154,0.0005345201,0.0004253969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704766,"about_ca_system_score_gemma":0.0002719038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005252478,"about_ca_topic_score_gemma":0.0006631289,"domain_scores_codex":[0.9998605,0.00002356305,0.0000114255,0.00002928908,0.0000509655,0.00002411392],"domain_scores_gemma":[0.9997965,0.00004157148,0.00004319276,0.00003995024,0.00001782891,0.0000610293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007386436,0.00001469086,0.000279466,0.00001432898,0.000004331221,0.00005970024,0.000007830959,0.0001255465,0.9984961,0.000102271,0.00000795465,0.0008140572],"study_design_scores_gemma":[0.00002337095,0.0002078273,0.008232459,0.000004623091,0.00001849235,0.0008299794,0.00001839655,0.001490007,0.988097,0.0001141016,0.000956241,0.000007608636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959884,0.0002020816,0.003215862,0.00003271348,0.000006217237,0.000008461395,0.00005498612,0.00004497863,0.0004463165],"genre_scores_gemma":[0.9979807,0.00004762195,0.001540079,0.00002185875,0.00000260209,0.000006043963,0.00009285218,0.00001411875,0.000294044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008101641,"threshold_uncertainty_score":0.002710283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1664362051476391,"score_gpt":0.3021266447674443,"score_spread":0.1356904396198053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}