{"id":"W2034745024","doi":"10.1126/science.1211936","title":"Imaging of <i>Plasmodium</i> Liver Stages to Drive Next-Generation Antimalarial Drug Discovery","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Malaria Research and Control","field":"Medicine","cited_by":347,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medicines for Malaria Venture; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; York University; Wellcome Trust; W. M. Keck Foundation","keywords":"Malaria; Drug discovery; Drug; Plasmodium (life cycle); Biology; Pharmacology; Drug development; In vivo; Computational biology; Parasite hosting; Immunology; Bioinformatics; Biotechnology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002302098,0.0003163901,0.0001999694,0.0001930734,0.00009734051,0.0002097209,0.0002473257,0.0002959659,0.001289291],"category_scores_gemma":[0.0001726433,0.0001717061,0.0001754659,0.0001478321,0.0001774029,0.0002645461,0.0002164844,0.0006013182,0.000185354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364325,"about_ca_system_score_gemma":0.0001890689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005228437,"about_ca_topic_score_gemma":0.001398324,"domain_scores_codex":[0.9999385,0.00001420247,0.000002804581,0.00001231985,0.00001771117,0.0000143704],"domain_scores_gemma":[0.999935,0.0000210262,0.00001740602,0.000006043136,0.000009817654,0.00001074538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003618983,0.00001240871,0.0001135551,0.00004244373,0.000002322738,0.0000210566,0.000005645456,0.0002518071,0.996336,0.0001358195,0.00007444695,0.002968279],"study_design_scores_gemma":[0.00002289443,0.0004673954,0.001836048,0.000008210245,0.00001187899,0.0002018122,0.00001698927,0.004504869,0.9901073,0.0001379488,0.00267856,0.000006028287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8778768,0.008554602,0.1019417,0.0008564009,0.00005586076,0.00031108,0.0008693076,0.0005177504,0.009016566],"genre_scores_gemma":[0.9143569,0.003793525,0.0787004,0.0001631854,0.00001940601,0.0001121929,0.0004009274,0.00004329599,0.00241015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289291,"threshold_uncertainty_score":0.004313052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04020725118080923,"score_gpt":0.2802556584072207,"score_spread":0.2400484072264114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}