{"id":"W2034770647","doi":"10.1089/hum.2012.083","title":"Lentiviral Gene Therapy Against Human Immunodeficiency Virus Type 1, Using a Novel Human TRIM21-Cyclophilin A Restriction Factor","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institutes of Health; Great Ormond Street Hospital Charity; University College London Hospitals NHS Foundation Trust; National Institute for Health and Care Research; Wellcome Trust","keywords":"Genetic enhancement; Virology; Cyclophilin A; Human immunodeficiency virus (HIV); Biology; Lentivirus; Gene; Virus; Severe combined immunodeficiency; Factor IX; Genetics; Molecular biology; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217414,0.0002725992,0.0001819028,0.0001710607,0.0001357285,0.0002767987,0.0001825517,0.0002890148,0.0007302642],"category_scores_gemma":[0.00006695426,0.00007915012,0.0002396588,0.0001314184,0.0001746232,0.0001349223,0.0001285377,0.0003806859,0.0002416833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565715,"about_ca_system_score_gemma":0.0001655781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004266074,"about_ca_topic_score_gemma":0.0006051746,"domain_scores_codex":[0.9999201,0.00001288875,0.000008011035,0.00001944402,0.00002502474,0.00001449808],"domain_scores_gemma":[0.9999671,0.000004992287,0.00001083009,0.000005994853,0.000002967894,0.000008068758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006055505,0.00003716693,0.0001676929,0.00003404176,0.00001353467,0.00006983343,0.00001142871,0.0001080543,0.9959564,0.0002129276,0.00007800533,0.003250342],"study_design_scores_gemma":[0.00002468846,0.0003606068,0.001449696,0.000003923838,0.00003184129,0.0005592609,0.000006363601,0.0009994716,0.9917053,0.00004505294,0.004809835,0.000003934314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986447,0.002924947,0.007526036,0.00009964588,0.00005516667,0.0001321987,0.000439977,0.0001660886,0.002209019],"genre_scores_gemma":[0.9910367,0.001152661,0.004738472,0.00006001718,0.00001721092,0.00005308138,0.0004364471,0.00001363678,0.002491785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007302642,"threshold_uncertainty_score":0.00258708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205931132380437,"score_gpt":0.3457557569832203,"score_spread":0.2251626437451766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}