{"id":"W2034770647","doi":"10.1089/hum.2012.083","title":"Lentiviral Gene Therapy Against Human Immunodeficiency Virus Type 1, Using a Novel Human TRIM21-Cyclophilin A Restriction Factor","year":2012,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institutes of Health; Great Ormond Street Hospital Charity; University College London Hospitals NHS Foundation Trust; National Institute for Health and Care Research; Wellcome Trust","keywords":"Genetic enhancement; Virology; Cyclophilin A; Human immunodeficiency virus (HIV); Biology; Lentivirus; Gene; Virus; Severe combined immunodeficiency; Factor IX; Genetics; Molecular biology; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003635854,0.0004697755,0.0004693344,0.0003536508,0.001564858,0.00006529717,0.0004186734,0.0003287408,0.001381156],"category_scores_gemma":[0.000008958988,0.0003952128,0.000248329,0.000335878,0.0002743088,0.0002565103,0.00008404704,0.0004571633,0.0005697634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002602844,"about_ca_system_score_gemma":0.0001026155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006061262,"about_ca_topic_score_gemma":0.00003182302,"domain_scores_codex":[0.9973295,0.000351579,0.0005171286,0.0005206431,0.0001570723,0.001124102],"domain_scores_gemma":[0.9988211,0.00003880415,0.0002216872,0.0007061926,0.0001233303,0.00008881719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003273013,0.001922233,0.004051638,0.000003531139,0.0004514054,0.000006382092,0.001155249,0.000004895227,0.986842,0.0002447894,0.0001495378,0.004841053],"study_design_scores_gemma":[0.009414803,0.001929326,0.0881111,0.00002054627,0.00002717576,0.00004629919,0.0001106332,0.000001687748,0.8786312,0.0001578331,0.02088587,0.0006634736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740688,0.02336935,0.00008962015,0.00001888881,0.0005019188,0.0007593478,0.0001425091,0.0001609276,0.0008886062],"genre_scores_gemma":[0.9942118,0.003142578,0.0001081334,0.0001072596,0.0002683102,0.00005585821,0.0009053214,0.00007980485,0.001120954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1082107,"threshold_uncertainty_score":0.99985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1205931132380437,"score_gpt":0.3457557569832203,"score_spread":0.2251626437451766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}