{"id":"W2034784902","doi":"10.1210/me.2011-0018","title":"Mechanisms of Melanocortin-2 Receptor (MC2R) Internalization and Recycling in Human Embryonic Kidney (HEK) Cells: Identification of Key Ser/Thr (S/T) Amino Acids","year":2011,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Biology; Cell biology; Endosome; Receptor; Melanocortin; HEK 293 cells; Intracellular; G protein-coupled receptor; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329211,0.0001945765,0.0003104527,0.0001924923,0.00003766991,0.00000846229,0.000256945,0.000199628,0.0001092852],"category_scores_gemma":[0.0000900524,0.0002120264,0.00009654344,0.0001290318,0.00009885531,0.000009630211,0.0001627224,0.000120561,0.000003166848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001750108,"about_ca_system_score_gemma":0.00004110637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001259059,"about_ca_topic_score_gemma":0.00002045368,"domain_scores_codex":[0.9982916,0.0001713857,0.0006593756,0.0004504905,0.000129494,0.0002977045],"domain_scores_gemma":[0.9990083,0.000007123123,0.0004182592,0.0003704639,0.0001190867,0.00007675613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006398228,0.00007993749,0.001082694,0.00006557647,0.00005662397,0.000007741463,0.0002167284,0.00003091128,0.9879801,0.009733258,0.00001882935,0.0006636235],"study_design_scores_gemma":[0.000628064,0.0003985051,0.0005698273,0.00004668127,0.00002771635,0.0000150404,0.0001266732,0.0001014411,0.9944034,0.003185581,0.0003176677,0.0001794608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8869777,0.000341634,0.1119267,0.00002079314,0.0002158262,0.000230079,0.00001553454,0.00001151779,0.0002602226],"genre_scores_gemma":[0.9959756,0.0002539967,0.00335285,0.00008515247,0.00001910947,0.00002863559,0.0001250669,0.00003414969,0.0001254497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1089979,"threshold_uncertainty_score":0.8646187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229011126259249,"score_gpt":0.2396632195562267,"score_spread":0.2273731082936342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}