{"id":"W2034784902","doi":"10.1210/me.2011-0018","title":"Mechanisms of Melanocortin-2 Receptor (MC2R) Internalization and Recycling in Human Embryonic Kidney (HEK) Cells: Identification of Key Ser/Thr (S/T) Amino Acids","year":2011,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Biology; Cell biology; Endosome; Receptor; Melanocortin; HEK 293 cells; Intracellular; G protein-coupled receptor; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002834988,0.0002292014,0.0003485021,0.0001872096,0.0002194584,0.0004782426,0.0004171517,0.0004427921,0.0006428531],"category_scores_gemma":[0.0001369277,0.0001903044,0.000544212,0.0001893789,0.0001797945,0.000408613,0.0002344765,0.0004322178,0.0005241892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000559716,"about_ca_system_score_gemma":0.0002283079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016508,"about_ca_topic_score_gemma":0.0007539292,"domain_scores_codex":[0.9997321,0.00004278547,0.0000349063,0.00005815229,0.00007886063,0.00005314764],"domain_scores_gemma":[0.9999454,0.00001041618,0.00001285101,0.00001027909,0.00001314157,0.000007970445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110241,0.000007811504,0.0001538597,0.00005700705,0.000007630376,0.00007225697,0.00002588795,0.00007540346,0.9981911,0.0002181069,0.00002511356,0.001055607],"study_design_scores_gemma":[0.0000151856,0.00008137547,0.00340282,0.000009672894,0.00001900988,0.0006872132,0.00003325151,0.002811051,0.9906169,0.00009661521,0.002213739,0.000013105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650119,0.008793556,0.02175995,0.0003308281,0.00007998244,0.00008312117,0.0008814656,0.0002449585,0.002814287],"genre_scores_gemma":[0.9742958,0.003500161,0.01726306,0.0001399036,0.00001726305,0.00008017472,0.0009725481,0.00005683092,0.003674247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016508,"threshold_uncertainty_score":0.004061043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229011126259249,"score_gpt":0.2396632195562267,"score_spread":0.2273731082936342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}