{"id":"W2034812820","doi":"10.1016/j.radonc.2014.05.001","title":"Epigenetics in radiotherapy: Where are we heading?","year":2014,"lang":"en","type":"review","venue":"Radiotherapy and Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Radiation therapy; Epigenetics; Medicine; Histone deacetylase; Epigenetic therapy; Histone deacetylase inhibitor; Cancer research; Cancer; Clinical trial; Bioinformatics; Oncology; Histone; Internal medicine; DNA methylation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005920966,0.0005417083,0.001775922,0.0002290022,0.00008286898,0.00003918924,0.0003042329,0.001374934,0.00005773133],"category_scores_gemma":[0.00002759362,0.0004870799,0.0003080959,0.0001913166,0.0001668116,0.000002999644,0.0000545747,0.0003755739,0.000004001013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667147,"about_ca_system_score_gemma":0.0002877526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001906518,"about_ca_topic_score_gemma":0.0004946773,"domain_scores_codex":[0.9972419,0.0006640254,0.0007227638,0.0007855664,0.0001225642,0.0004631771],"domain_scores_gemma":[0.9986507,0.0001361567,0.0004850592,0.0005304753,0.0000402082,0.0001573641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003827665,0.00008993545,0.0002979321,0.002049705,0.0001720561,0.00001253636,0.00007910261,0.00002414134,0.0005756326,0.00005796516,0.0009430271,0.9956597],"study_design_scores_gemma":[0.000849844,0.0008776505,0.00003056759,0.001088405,0.00008338863,0.00003645592,0.00001230654,0.00004935645,0.00006503263,0.00007199832,0.9963156,0.0005194061],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002943871,0.9952066,0.002729137,0.000308542,0.0004320195,0.0006369043,0.00002283975,0.0000154656,0.0003541126],"genre_scores_gemma":[0.00003665696,0.9951059,0.002486293,0.0002259444,0.001096504,0.0001005482,0.00008757949,0.000124914,0.0007356778],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9953725,"threshold_uncertainty_score":0.9999215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306224713391508,"score_gpt":0.3578515768519503,"score_spread":0.3272291055127995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}