{"id":"W2034854968","doi":"10.1289/ehp.0800073","title":"Predicting Plasma Concentrations of Bisphenol A in Children Younger Than 2 Years of Age after Typical Feeding Schedules, using a Physiologically Based Toxicokinetic Model","year":2008,"lang":"en","type":"article","venue":"Environmental Health Perspectives","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Waterloo","funders":"","keywords":"Toxicokinetics; Bisphenol A; Physiologically based pharmacokinetic modelling; Chemistry; Tolerable daily intake; Xenoestrogen; Benzhydryl compounds; Glucuronidation; Pharmacokinetics; Physiology; Endocrinology; Metabolite; Internal medicine; Toxicology; Medicine; Body weight; Biochemistry; Biology; Microsome; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003680654,0.0006470707,0.0003434007,0.0002765291,0.0001543179,0.0004253892,0.0004317346,0.0008621595,0.0008124207],"category_scores_gemma":[0.001289435,0.0003142609,0.0007931598,0.0001893692,0.0001978794,0.0002589881,0.0003059233,0.0004281558,0.0002413775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006645677,"about_ca_system_score_gemma":0.0008533836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01409735,"about_ca_topic_score_gemma":0.006071468,"domain_scores_codex":[0.999894,0.0000244914,0.000006444257,0.00004278465,0.00001634908,0.00001588154],"domain_scores_gemma":[0.9994953,0.0003263632,0.00008976538,0.0000133577,0.00004931367,0.00002591542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001553251,0.0000407109,0.03279567,0.00002900235,0.00004517206,0.0001409336,0.00003756041,0.9588206,0.003400119,0.0002014096,0.0001020135,0.004231547],"study_design_scores_gemma":[0.00001564853,0.0002070058,0.01011797,0.000006435093,0.0000436777,0.0001460769,0.00002440527,0.9870524,0.001705713,0.000368208,0.0003002719,0.0000121508],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9231383,0.0002611641,0.07475954,0.0001024186,0.00001300681,0.00004474079,0.0006424804,0.0001394982,0.0008989557],"genre_scores_gemma":[0.9882693,0.000215182,0.01013732,0.00003580188,0.000004389248,0.00007091194,0.0005024265,0.00001519302,0.0007495661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01409735,"threshold_uncertainty_score":0.02803063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514305727425086,"score_gpt":0.3007867728644039,"score_spread":0.285643715590153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}