{"id":"W2034858347","doi":"10.2174/1566523054546233","title":"Retrovirus Silencing and Vector Design: Relevance to Normal and Cancer Stem Cells?","year":2005,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"Hospital for Sick Children; Stem Cell Network","keywords":"Biology; Gene silencing; Stem cell; Epigenetics; Retrovirus; Vector (molecular biology); Chromatin; DNA methylation; Histone; Variegation (histology); Viral vector; RNA interference; Cell biology; Cancer research; Genetics; Gene; Gene expression; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001676212,0.001043483,0.001549748,0.001313778,0.0002239617,0.001310003,0.00166649,0.002095215,0.001452229],"category_scores_gemma":[0.00114221,0.0004081559,0.0003985938,0.00172394,0.001695358,0.002596054,0.0004675705,0.002504161,0.001982546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001132994,"about_ca_system_score_gemma":0.0006981561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007564221,"about_ca_topic_score_gemma":0.0007254287,"domain_scores_codex":[0.9994299,0.0001137909,0.00007166606,0.00009540028,0.0002635588,0.00002562404],"domain_scores_gemma":[0.9994937,0.0002331242,0.00007023582,0.00004183981,0.000126215,0.00003497041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009995272,0.00007840652,0.0002474203,0.00758563,0.00005678122,0.0004711004,0.0001800059,0.001077016,0.02850606,0.02956042,0.01413519,0.918002],"study_design_scores_gemma":[0.00003348412,0.0001818069,0.0005221608,0.000944977,0.00005183467,0.002637034,0.00008003099,0.0003199903,0.01115324,0.009035425,0.975001,0.00003894846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006164885,0.9906007,0.005471763,0.0007366118,0.0005233779,0.00001651998,0.00002342945,0.00004665399,0.001964449],"genre_scores_gemma":[0.00302358,0.9880751,0.005050784,0.000770579,0.0002388403,0.00003956695,0.00006332719,0.00001911208,0.002719238],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002095215,"threshold_uncertainty_score":0.00886476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09692672178414298,"score_gpt":0.3854021522531232,"score_spread":0.2884754304689802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}