{"id":"W2034858347","doi":"10.2174/1566523054546233","title":"Retrovirus Silencing and Vector Design: Relevance to Normal and Cancer Stem Cells?","year":2005,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"Hospital for Sick Children; Stem Cell Network","keywords":"Biology; Gene silencing; Stem cell; Epigenetics; Retrovirus; Vector (molecular biology); Chromatin; DNA methylation; Histone; Variegation (histology); Viral vector; RNA interference; Cell biology; Cancer research; Genetics; Gene; Gene expression; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004416642,0.0006027788,0.000856323,0.0001426791,0.0001466609,0.00008032264,0.0004152062,0.0002958097,0.0000441585],"category_scores_gemma":[0.00001045549,0.0005196547,0.0001813576,0.0002149217,0.0001206772,0.000007415663,0.0001918808,0.0003723448,0.00003235848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009967468,"about_ca_system_score_gemma":0.0004439366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008174759,"about_ca_topic_score_gemma":0.00002372211,"domain_scores_codex":[0.997354,0.0003643095,0.0004370683,0.0009702881,0.000278983,0.0005953382],"domain_scores_gemma":[0.998713,0.00005248959,0.0001919855,0.0006379457,0.00009223982,0.0003123248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004473577,0.00003648927,0.000002505808,0.0006713393,0.0001311845,0.000001994335,0.00005046198,0.00002045883,0.05337971,6.210046e-7,0.0008247257,0.9444332],"study_design_scores_gemma":[0.0004814498,0.001508037,0.000002057702,0.0008593349,0.00006097672,0.00001250894,0.000004205301,0.000009413362,0.0879791,0.000001523461,0.9085084,0.0005729877],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01563274,0.9822258,0.0002194623,0.00003110886,0.0004286329,0.001306864,0.0001255637,0.00002219683,0.00000766676],"genre_scores_gemma":[0.0003017604,0.9972265,0.0002575915,0.0001130274,0.001261123,0.0003859103,0.00004250972,0.0001292678,0.0002823055],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9438602,"threshold_uncertainty_score":0.9997255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09692672178414298,"score_gpt":0.3854021522531232,"score_spread":0.2884754304689802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}