{"id":"W2034878791","doi":"10.1074/jbc.m109.077834","title":"PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Stiftelsen Lars Hiertas Minne; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; Pain Relief Foundation","keywords":"Poly ADP ribose polymerase; DNA repair; Biology; PARP inhibitor; DNA; Histone; Molecular biology; Topoisomerase; Cell biology; Genetics; Polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005341462,0.0001317322,0.0003557895,0.00002732832,0.0000263829,0.00001044857,0.0002694514,0.0002252443,0.0007386213],"category_scores_gemma":[0.0002886502,0.00006794338,0.000183673,0.0001433047,0.0002497812,0.00005290287,0.00002456879,0.0008322528,0.000003779877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003444375,"about_ca_system_score_gemma":0.0000883237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000398821,"about_ca_topic_score_gemma":4.762099e-7,"domain_scores_codex":[0.9989237,0.00003762276,0.0004360093,0.0001372786,0.0002836239,0.0001818135],"domain_scores_gemma":[0.998819,0.0002943298,0.0004311199,0.0002379423,0.0001133393,0.0001043028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004029408,0.0002300228,0.04787467,0.00003601312,0.00002794665,0.00006866915,0.0001797552,7.310756e-7,0.9489757,0.000008745791,0.001498771,0.0006960655],"study_design_scores_gemma":[0.001155696,0.0001890297,0.02821093,0.0001261791,0.00001143847,0.0005327564,0.0003266885,0.000006712361,0.9630925,0.0009398101,0.005327897,0.00008033457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946955,0.0002902158,0.00001488757,0.00331773,0.00007285662,0.00007753105,0.000009911091,0.000006510738,0.001514902],"genre_scores_gemma":[0.9980744,0.0003483233,0.0002648197,0.0008911664,0.0003488544,0.000006022883,0.000002809606,0.000005769178,0.00005782588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01966374,"threshold_uncertainty_score":0.8087385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04951507774460018,"score_gpt":0.3203466072043329,"score_spread":0.2708315294597328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}