{"id":"W2034878791","doi":"10.1074/jbc.m109.077834","title":"PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Stiftelsen Lars Hiertas Minne; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust; Pain Relief Foundation","keywords":"Poly ADP ribose polymerase; DNA repair; Biology; PARP inhibitor; DNA; Histone; Molecular biology; Topoisomerase; Cell biology; Genetics; Polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588715,0.0004917985,0.0002962736,0.0002162441,0.0002692385,0.0005151515,0.0002649867,0.000454346,0.002586602],"category_scores_gemma":[0.0002366808,0.0001858068,0.0008076918,0.0003770821,0.000198392,0.0003074956,0.0002442703,0.0008627565,0.001648757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834506,"about_ca_system_score_gemma":0.0001513484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004038931,"about_ca_topic_score_gemma":0.0003151279,"domain_scores_codex":[0.9997916,0.00002990939,0.00001750112,0.00006999039,0.00005525976,0.00003575669],"domain_scores_gemma":[0.9997484,0.00003508737,0.0001048119,0.00004558036,0.00003495351,0.00003123969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594781,0.000047936,0.001960224,0.0001273063,0.0000472456,0.0002650302,0.00003294725,0.0003353996,0.9871982,0.0003062596,0.0002661833,0.009253812],"study_design_scores_gemma":[0.00001329293,0.0003062086,0.01602904,0.00001841535,0.00004878069,0.002672574,0.00004129553,0.00104717,0.9597747,0.0003982235,0.01962974,0.00002075036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9195389,0.01248356,0.05484353,0.0004658344,0.0001319202,0.0001416532,0.004456193,0.0004374416,0.007501156],"genre_scores_gemma":[0.9719301,0.00362105,0.01254424,0.000224094,0.00002921485,0.00005205264,0.006342643,0.00005646555,0.005200144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002586602,"threshold_uncertainty_score":0.008653045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04951507774460018,"score_gpt":0.3203466072043329,"score_spread":0.2708315294597328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}