{"id":"W2034883288","doi":"10.1016/j.gene.2006.07.032","title":"Stochastic epigenetic silencing of retrotransposons: Does stability come with age?","year":2006,"lang":"en","type":"review","venue":"Gene","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"BC Cancer Agency; Canadian Institutes of Health Research; Multiple Sclerosis Scientific Research Foundation","keywords":"Biology; Retrotransposon; Epigenetics; Transposable element; Genetics; DNA methylation; Gene silencing; Endogenous retrovirus; Phenotype; Germline; Somatic cell; Long terminal repeat; Gene; Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424351,0.0002930832,0.0009224752,0.00001641959,0.0001144361,0.00002301384,0.0003087634,0.0001819804,0.0003529853],"category_scores_gemma":[0.00002094488,0.00008312952,0.0002745678,0.0004330638,0.0001154966,0.00002088113,0.00004347926,0.0001498075,0.00001237982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004277899,"about_ca_system_score_gemma":0.00005003799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003577954,"about_ca_topic_score_gemma":0.002080817,"domain_scores_codex":[0.9984093,0.0001216554,0.0005167564,0.0004226283,0.0002501743,0.0002794892],"domain_scores_gemma":[0.9991668,0.000268108,0.0002683815,0.0001466542,0.00006867074,0.00008134202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001134224,0.0002427473,0.0002174148,0.003184719,0.0001342045,0.00001537366,0.00007803876,0.00007281621,0.006390569,0.00005083515,0.00001249305,0.9895895],"study_design_scores_gemma":[0.001116337,0.004111224,0.03296074,0.02405497,0.006546188,0.0001881923,0.0002949037,0.00005981259,0.004642743,0.003679028,0.9172637,0.005082206],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02971749,0.9683434,0.00006616011,0.00003187952,0.0001051524,0.0007678174,0.0008161949,0.00004050503,0.0001113475],"genre_scores_gemma":[0.04350614,0.9545787,0.0005974213,0.00000985851,0.0003947716,0.0001193573,0.0006320132,0.000004613025,0.0001571309],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9845073,"threshold_uncertainty_score":0.3864942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04145722730537992,"score_gpt":0.2501311570404688,"score_spread":0.2086739297350889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}