{"id":"W2034921833","doi":"10.1038/cddis.2011.54","title":"Ocular neuroprotection by siRNA targeting caspase-2","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Wellcome Trust","keywords":"Neuroprotection; Small interfering RNA; Optic nerve; Retinal ganglion cell; Caspase 3; Retina; Anterior ischemic optic neuropathy; Caspase 2; RNA interference; Glaucoma; Intravitreal administration; Apoptosis; Optic neuropathy; Biology; Pharmacology; Cell biology; Neuroscience; Biochemistry; RNA; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153979,0.000278529,0.0001736135,0.0002022546,0.0001083754,0.000224567,0.0001167771,0.0002194839,0.001076891],"category_scores_gemma":[0.0000971142,0.00007783124,0.0001576669,0.00007220433,0.0001765397,0.0001750397,0.0001002256,0.0003331272,0.000193642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873254,"about_ca_system_score_gemma":0.000228784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006093929,"about_ca_topic_score_gemma":0.001024084,"domain_scores_codex":[0.9999385,0.000009095225,0.000007363986,0.00001344004,0.00001538341,0.00001621209],"domain_scores_gemma":[0.9999563,0.000008584632,0.00001456021,0.000004872641,0.000007180764,0.000008552658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001451297,0.00002510898,0.0000656577,0.00003665053,0.000004263653,0.00003126025,0.000009568588,0.0000411427,0.9970595,0.000087853,0.0000531287,0.002440689],"study_design_scores_gemma":[0.0000414845,0.0006795336,0.001192749,0.000005178028,0.00001690511,0.0001388625,0.00001176244,0.0006091712,0.9957511,0.00004411494,0.001506147,0.000002976524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992543,0.002990298,0.001934162,0.0001632967,0.00004418619,0.00002099577,0.0001138375,0.000122977,0.00206728],"genre_scores_gemma":[0.9947478,0.001369285,0.001451988,0.00005494702,0.0000147594,0.00002182977,0.0001551158,0.00001392282,0.002170324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076891,"threshold_uncertainty_score":0.003602505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158234638937521,"score_gpt":0.1978082680632555,"score_spread":0.1862259216738803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}