{"id":"W2034921833","doi":"10.1038/cddis.2011.54","title":"Ocular neuroprotection by siRNA targeting caspase-2","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":164,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Wellcome Trust","keywords":"Neuroprotection; Small interfering RNA; Optic nerve; Retinal ganglion cell; Caspase 3; Retina; Anterior ischemic optic neuropathy; Caspase 2; RNA interference; Glaucoma; Intravitreal administration; Apoptosis; Optic neuropathy; Biology; Pharmacology; Cell biology; Neuroscience; Biochemistry; RNA; Programmed cell death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003698979,0.0000989348,0.0000543494,0.00001512051,0.0000728015,0.00001574173,0.00006225237,0.00004629591,0.00004520261],"category_scores_gemma":[0.00003250916,0.00009227642,0.00004699392,0.00002108019,0.00002468897,0.000004170079,0.00004454331,0.00004167233,0.00001935826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002331967,"about_ca_system_score_gemma":0.00002550345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004934277,"about_ca_topic_score_gemma":9.821492e-7,"domain_scores_codex":[0.9994506,0.00002414067,0.00008321122,0.0002472877,0.00004751091,0.0001472292],"domain_scores_gemma":[0.9995312,0.000001445624,0.00002883696,0.0001482039,0.00002955303,0.000260745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002703921,0.0001174186,0.01125327,0.0000399934,0.00001411047,0.00004676429,0.00004557769,0.000003277072,0.973511,0.00001959844,0.01306486,0.001613695],"study_design_scores_gemma":[0.0007773622,0.0005431226,0.009879294,0.000013768,0.00008187608,0.000008000754,0.0001103809,0.0002759995,0.9577133,0.0004547131,0.02966063,0.0004815453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924179,0.003421309,0.001003127,0.00001595912,0.0000771559,0.00008960669,0.0000204374,0.00001145815,0.002943075],"genre_scores_gemma":[0.9980485,0.0003749134,0.00009680996,0.0004056107,0.00008403893,0.00001274732,0.00008737535,0.00001137444,0.0008786158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01659577,"threshold_uncertainty_score":0.3762923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158234638937521,"score_gpt":0.1978082680632555,"score_spread":0.1862259216738803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}