{"id":"W2034945606","doi":"10.1016/j.bmcl.2010.09.134","title":"N,N-Bis-(8-hydroxyquinoline-5-yl methyl)-benzyl substituted amines (HQNBA): Peroxisome proliferator-activated receptor (PPAR-γ) agonists with neuroprotective properties","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Centre National de la Recherche Scientifique","keywords":"Chemistry; Neuroprotection; Oxidative stress; Peroxisome proliferator-activated receptor; Peroxisome; Pharmacology; Receptor; Stereochemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001577815,0.000207876,0.0002064337,0.0001280898,0.0001229775,0.00008461191,0.0003224153,0.0002587405,0.00236212],"category_scores_gemma":[0.0000974189,0.00008325577,0.00009900534,0.00009078032,0.0001297366,0.0002052586,0.0001152412,0.0002693184,0.0008283952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001325462,"about_ca_system_score_gemma":0.0001098846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000318863,"about_ca_topic_score_gemma":0.0006031322,"domain_scores_codex":[0.9999464,0.00001579449,0.0000042533,0.000009802263,0.00001127071,0.00001246626],"domain_scores_gemma":[0.9999584,0.000005820776,0.00001199473,0.000004050108,0.000007832069,0.00001182274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005925365,0.00007405029,0.000133617,0.0001930786,0.0000107945,0.0001700661,0.00002570103,0.0002166209,0.9821004,0.0009188805,0.0005808874,0.01498338],"study_design_scores_gemma":[0.0001962959,0.001849823,0.002240812,0.00002566984,0.00003974564,0.0009898636,0.00003834002,0.0009451444,0.9681345,0.0002745574,0.0252461,0.00001926951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9294195,0.02569631,0.01987741,0.000849577,0.0004681184,0.0001036834,0.0006534104,0.0006200201,0.02231195],"genre_scores_gemma":[0.9830815,0.005320555,0.004441314,0.0002381614,0.00006492864,0.00005975584,0.0002509457,0.00002014306,0.00652268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00236212,"threshold_uncertainty_score":0.007902145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006616803368440186,"score_gpt":0.1984381600106438,"score_spread":0.1918213566422036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}