{"id":"W2034946866","doi":"10.1016/j.bmcl.2008.10.026","title":"Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Reboxetine; Atomoxetine; Reuptake inhibitor; Norepinephrine; Selectivity; Norepinephrine transporter; Reuptake; Potency; Chemical synthesis; Stereochemistry; Pharmacology; Dopamine; Serotonin; Biochemistry; In vitro; Internal medicine; Receptor; Attention deficit hyperactivity disorder","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001347563,0.0004599013,0.0003989833,0.0002623911,0.00020093,0.0002985633,0.0006375554,0.0002916483,0.002698391],"category_scores_gemma":[0.0001196756,0.0002463122,0.0002247808,0.0001708567,0.0001576795,0.0002960277,0.0002072294,0.0004551312,0.0008914095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000323575,"about_ca_system_score_gemma":0.000363794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005604004,"about_ca_topic_score_gemma":0.002222053,"domain_scores_codex":[0.9999254,0.00001082535,0.000007515906,0.00001192844,0.00001470251,0.00002967421],"domain_scores_gemma":[0.9999546,0.000007409739,0.00001269242,0.000004121259,0.00000768736,0.00001357396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006789582,0.0002812761,0.0002199008,0.0005640304,0.00003998192,0.0006805264,0.0001293203,0.001102407,0.9549273,0.00214534,0.001146815,0.03808414],"study_design_scores_gemma":[0.0006439744,0.004677494,0.003454233,0.00007633748,0.000167916,0.001548056,0.00006263077,0.002523826,0.941812,0.0004126411,0.04454538,0.00007528878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9212579,0.03525214,0.01459127,0.0007491434,0.0003927378,0.0005257517,0.002211663,0.0004219968,0.02459743],"genre_scores_gemma":[0.958995,0.01695709,0.007607276,0.0002895234,0.00009663227,0.0002090104,0.001924957,0.00004599206,0.01387463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002698391,"threshold_uncertainty_score":0.009027004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892783049746787,"score_gpt":0.2521734727483981,"score_spread":0.2332456422509302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}