{"id":"W2034994301","doi":"10.1016/j.expneurol.2009.02.002","title":"Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity","year":2009,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Directorate for Biological Sciences; Fondation pour la Recherche sur Alzheimer","keywords":"THP1 cell line; Microglia; Neurotoxicity; Pharmacology; Tumor necrosis factor alpha; Lipopolysaccharide; Chemistry; Neuroinflammation; Interleukin; Inflammation; Cell culture; Toxicity; Cytokine; Medicine; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002442531,0.0006316782,0.0005169173,0.0002743906,0.0003845545,0.0003079755,0.0002369663,0.0003464319,0.003067309],"category_scores_gemma":[0.000196803,0.000212166,0.00031024,0.0003043181,0.0002667112,0.0002805419,0.0001756797,0.0009209781,0.0007071856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095899,"about_ca_system_score_gemma":0.0003966882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009951455,"about_ca_topic_score_gemma":0.001891442,"domain_scores_codex":[0.999816,0.0000398914,0.00001617474,0.00001386955,0.00003038957,0.0000836582],"domain_scores_gemma":[0.9998956,0.00003047142,0.00002269286,0.00001414857,0.00001256426,0.00002466046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004969497,0.000612366,0.0003041178,0.0002704266,0.00004043639,0.0002828673,0.00007596734,0.0001066591,0.9860465,0.0001416998,0.0008266767,0.006322796],"study_design_scores_gemma":[0.0005406345,0.004805076,0.009445897,0.00002213582,0.0001015641,0.0007830641,0.0001239562,0.0003054885,0.9801123,0.00009442867,0.003651879,0.0000136608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850768,0.009112525,0.001154465,0.000415022,0.0001493014,0.00005949342,0.001302207,0.0001059556,0.002624157],"genre_scores_gemma":[0.9843726,0.007888761,0.001906195,0.000152815,0.0001256755,0.00009424801,0.00192566,0.00001831317,0.003515682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003067309,"threshold_uncertainty_score":0.01026118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122796943682624,"score_gpt":0.2548256091618619,"score_spread":0.2425459147935995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}