{"id":"W2035027484","doi":"10.1002/art.22740","title":"Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor–associated periodic syndrome is altered antigenically and is retained within patients' leukocytes","year":2007,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Mutant; Receptor; Tumor necrosis factor alpha; Monoclonal antibody; Mutation; Molecular biology; Antibody; In vitro; Transfection; Biology; Cell culture; Immunology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000435662,0.0007308761,0.0008901674,0.0001594501,0.0006029105,0.0002681513,0.0003979026,0.0004080186,0.001000363],"category_scores_gemma":[0.0007431711,0.000702948,0.0002739279,0.0004029647,0.0004208134,0.00008001777,0.0002115827,0.0004037691,0.00006727073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001041069,"about_ca_system_score_gemma":0.0002222357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003719749,"about_ca_topic_score_gemma":0.0008481676,"domain_scores_codex":[0.9958711,0.0001956668,0.001174282,0.00105734,0.0005880775,0.001113583],"domain_scores_gemma":[0.997665,0.00009281434,0.0008002975,0.000630201,0.000475805,0.0003358888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00103262,0.001058152,0.2824258,0.0001052756,0.001855041,0.00006578805,0.01206943,0.000002273574,0.6707896,0.00003019102,0.009242828,0.02132295],"study_design_scores_gemma":[0.01417034,0.005550966,0.5784782,0.002082668,0.0001154533,0.00009559149,0.001788798,0.0000805977,0.3917217,0.00008398621,0.003034194,0.002797544],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956779,0.001560171,0.00005468704,0.0002022586,0.0003962243,0.0008196127,0.001065196,0.0001111588,0.0001128305],"genre_scores_gemma":[0.994884,0.001872177,0.0003583817,0.001056742,0.00002906408,0.00005043551,0.001189348,0.0001428294,0.0004169903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2960523,"threshold_uncertainty_score":0.9999129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006189684278180121,"score_gpt":0.2048242609465647,"score_spread":0.1986345766683846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}