{"id":"W2035027484","doi":"10.1002/art.22740","title":"Mutant tumor necrosis factor receptor associated with tumor necrosis factor receptor–associated periodic syndrome is altered antigenically and is retained within patients' leukocytes","year":2007,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Mutant; Receptor; Tumor necrosis factor alpha; Monoclonal antibody; Mutation; Molecular biology; Antibody; In vitro; Transfection; Biology; Cell culture; Immunology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001466832,0.0003150516,0.0002301887,0.0001739053,0.0001135624,0.0001757172,0.0001162134,0.0003175696,0.001410469],"category_scores_gemma":[0.0002885047,0.0001025493,0.0001570659,0.0001396004,0.0001901762,0.000128689,0.0001138427,0.0002129401,0.0002709127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001374896,"about_ca_system_score_gemma":0.00007752975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000332872,"about_ca_topic_score_gemma":0.0003033801,"domain_scores_codex":[0.999841,0.00002969109,0.00001831549,0.00004177539,0.00003997992,0.00002919161],"domain_scores_gemma":[0.9998549,0.00002620504,0.00007023635,0.0000100453,0.00001242369,0.00002619979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007467128,0.00005138777,0.02808009,0.00005830254,0.00003564826,0.005363021,0.0001015673,0.00009558092,0.9619766,0.00009015763,0.000108604,0.003292451],"study_design_scores_gemma":[0.000174319,0.002319206,0.5751212,0.00003052442,0.0001437561,0.1256202,0.0003569115,0.001632229,0.2910447,0.0001203723,0.003414623,0.00002196657],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993161,0.0001992106,0.0002437864,0.00001770816,0.000003013267,0.000003537011,0.00003145504,0.000007583491,0.000177746],"genre_scores_gemma":[0.9994903,0.00009132682,0.000185821,0.00001626981,0.000004529254,0.000003655847,0.00005736032,0.000002997928,0.0001477248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001410469,"threshold_uncertainty_score":0.004718423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006189684278180121,"score_gpt":0.2048242609465647,"score_spread":0.1986345766683846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}