{"id":"W2035031187","doi":"10.1111/j.1742-4658.2005.04851.x","title":"Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D","year":2005,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; McGill University","keywords":"Pepstatin; Endosome; Cathepsin D; Cathepsin B; Endocytic cycle; Cholera toxin; Biochemistry; Cathepsin; Cathepsin C; Biology; Proteolysis; Proteases; Endocytosis; Cell biology; Chemistry; Molecular biology; Protease; Enzyme; Intracellular; Receptor; Microbiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001976108,0.0001023021,0.0001251271,0.00004505657,0.00004955892,0.00002249788,0.0001218539,0.00008531284,0.0001208826],"category_scores_gemma":[0.00002893389,0.00008917494,0.00009806404,0.0000463109,0.00003481957,0.00001114659,0.0000123456,0.0001437229,0.000004870977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002301806,"about_ca_system_score_gemma":0.00005298022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000151556,"about_ca_topic_score_gemma":0.000009112217,"domain_scores_codex":[0.999245,0.00003911942,0.0003071841,0.000123029,0.0001568264,0.0001288221],"domain_scores_gemma":[0.999533,0.000003952334,0.0002098844,0.0001217363,0.00006677584,0.00006463513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001529731,0.00007107022,0.003113026,0.00001197995,0.00004080652,0.000001378836,0.0003509913,0.0001008446,0.9945773,0.00001019476,0.0001876902,0.001381736],"study_design_scores_gemma":[0.0009677432,0.0001866827,0.0009933163,0.00005207695,0.00001836801,0.0000586581,0.00003707199,0.000329055,0.9778391,0.0000470797,0.01936419,0.0001066391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668005,0.000413129,0.03206571,0.0003098096,0.0000874512,0.0001234913,0.000004086422,0.000004598959,0.0001912312],"genre_scores_gemma":[0.9975165,0.000111192,0.000844333,0.0001252888,0.0002647653,0.000005640307,0.0002105608,0.0000144962,0.0009072464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03122137,"threshold_uncertainty_score":0.3636449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007864695365131624,"score_gpt":0.229851230936629,"score_spread":0.2219865355714974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}