{"id":"W2035107300","doi":"10.1074/jbc.m410469200","title":"A Single Mms2 “Key” Residue Insertion into a Ubc13 Pocket Determines the Interface Specificity of a Human Lys63 Ubiquitin Conjugation Complex","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Saskatchewan","funders":"","keywords":"Ubiquitin; Key (lock); Residue (chemistry); Human–computer interaction; Interface (matter); Ubiquitin-conjugating enzyme; Computer science; Communication; Embedded system; Chemistry; Psychology; Biochemistry; Ubiquitin ligase; Parallel computing; Operating system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001540443,0.0003079567,0.0002186665,0.0001210932,0.0001969543,0.0002612239,0.0002635801,0.0002724475,0.0008358705],"category_scores_gemma":[0.0001556179,0.0001781838,0.0003040154,0.000146192,0.0002341872,0.0001201417,0.0001925054,0.0003558119,0.0003436987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005942777,"about_ca_system_score_gemma":0.0002626775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001397069,"about_ca_topic_score_gemma":0.002010105,"domain_scores_codex":[0.9998741,0.00002181135,0.00001375328,0.00003562791,0.00003122947,0.0000234799],"domain_scores_gemma":[0.9999155,0.00001577792,0.00002040464,0.00001086188,0.000007761817,0.000029716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002025477,0.00003677361,0.0008525995,0.0000180973,0.000007910839,0.0001468053,0.00001491548,0.0002916817,0.9972825,0.0001799518,0.00003459516,0.000931575],"study_design_scores_gemma":[0.00001544586,0.00008810447,0.003656736,0.000003407344,0.00001198692,0.0002415217,0.00002156903,0.002823218,0.9923289,0.00003819247,0.0007654434,0.000005474307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974868,0.00008539453,0.001937314,0.00002127796,0.000007607966,0.000008311195,0.00008638984,0.00003451544,0.0003323748],"genre_scores_gemma":[0.9976464,0.00003962833,0.001581732,0.00001749864,0.000001283035,0.000005586985,0.0002052458,0.0000141649,0.0004884699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397069,"threshold_uncertainty_score":0.0043118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04797908684185224,"score_gpt":0.2995453867356432,"score_spread":0.2515662998937909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}