{"id":"W2035125398","doi":"10.1016/s0168-8278(08)60066-5","title":"64 SAFETY OF THE HCV PROTEASE INHIBITOR TMC435350 IN HEALTHY VOLUNTEERS AND SAFETY AND ACTIVITY IN CHRONIC HEPATITIS C INFECTED INDIVIDUALS: A PHASE I STUDY","year":2008,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Protease inhibitor (pharmacology); Chronic hepatitis; Medicine; Virology; Hepatitis C; Protease; Pharmacology; Chemistry; Viral load; Virus; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001510141,0.0001953585,0.001004718,0.0006459211,0.0001042303,0.000006761904,0.0001426253,0.0001828439,0.00005333456],"category_scores_gemma":[0.001316425,0.0001438623,0.00007980422,0.0006477494,0.000443086,0.000197738,0.000171099,0.001159975,0.000001248181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000677474,"about_ca_system_score_gemma":0.001865533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004749557,"about_ca_topic_score_gemma":0.01289399,"domain_scores_codex":[0.996495,0.001210673,0.001080474,0.0002557041,0.0005405895,0.000417555],"domain_scores_gemma":[0.998475,0.0003502105,0.0004589603,0.0002643362,0.0002100209,0.0002415232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004552942,0.001449816,0.9785089,0.0001547035,0.00008612958,0.0006991121,0.001888508,0.000006535814,0.001160016,0.000004673245,0.00007434086,0.01141436],"study_design_scores_gemma":[0.02050217,0.006633747,0.96905,0.0002520022,0.00004074707,0.0008832167,0.0001007596,0.0007739519,0.0006057696,0.00001388004,0.001032222,0.0001115338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954003,0.0008263123,0.00002161653,0.001958878,0.00009806249,0.001572581,0.00002707839,0.000006098122,0.00008904329],"genre_scores_gemma":[0.9971666,0.002502553,0.00008099563,0.000125754,0.00006922647,0.0000206191,0.00000141896,0.0000199435,0.00001291932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01594923,"threshold_uncertainty_score":0.7195151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03063162184567443,"score_gpt":0.3492439805199131,"score_spread":0.3186123586742386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}