{"id":"W2035128466","doi":"10.1089/hum.2008.0106","title":"Restoration of Vitamin C Synthesis in Transgenic <i> Gulo <sup>−/−</sup> </i> Mice by Helper-Dependent Adenovirus-Based Expression of Gulonolactone Oxidase","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ascorbic acid; Vitamin C; Internal medicine; Endocrinology; Vitamin; Endogeny; Cell culture; Transgene; Chemistry; Biology; Biochemistry; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000253589,0.0006523087,0.0003067331,0.0005325911,0.0001990863,0.0005433065,0.0004189448,0.000553957,0.00155062],"category_scores_gemma":[0.0001727973,0.0003901119,0.0004744568,0.0001934731,0.0006972652,0.0002849162,0.0002515775,0.0009685147,0.000625336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004038766,"about_ca_system_score_gemma":0.0003175312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124095,"about_ca_topic_score_gemma":0.001636757,"domain_scores_codex":[0.9998032,0.0000257767,0.00003401516,0.00005179372,0.00004171338,0.00004350659],"domain_scores_gemma":[0.9995257,0.00005698004,0.0002202481,0.00004244978,0.0000288979,0.000125758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001104591,0.00002359123,0.00009951944,0.00001865483,0.000004511965,0.00004300987,0.00001307482,0.00003523094,0.9992517,0.0001199193,0.00002189574,0.0002584883],"study_design_scores_gemma":[0.00006556768,0.0005093297,0.002457317,0.00001163782,0.00003181687,0.0004000852,0.00004792667,0.0008780618,0.9929001,0.00006690592,0.002621648,0.000009573366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900093,0.0006141926,0.006221287,0.0001236318,0.00006900135,0.00006735095,0.001292286,0.0004181073,0.001184906],"genre_scores_gemma":[0.980615,0.0009201276,0.007189365,0.0001111268,0.00003278489,0.0001241158,0.002147887,0.0002874197,0.008572293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155062,"threshold_uncertainty_score":0.005187333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03772409168774261,"score_gpt":0.292065887322875,"score_spread":0.2543417956351324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}