{"id":"W2035129407","doi":"10.1002/ijc.10917","title":"Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: A preclinical model","year":2003,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Grantová Agentura České Republiky; Hilfe für krebskranke Kinder Frankfurt; Frankfurter Stiftung für krebskranke Kinder","keywords":"Neuroblastoma; Vincristine; Cell culture; Cytotoxic T cell; Doxorubicin; Cancer research; Cisplatin; Biology; P-glycoprotein; Karyotype; clone (Java method); Drug resistance; Chemotherapy; In vitro; Multiple drug resistance; Cyclophosphamide; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002782094,0.0004607684,0.0004271731,0.0003018294,0.0002146754,0.000277828,0.0004939175,0.0004085119,0.001586456],"category_scores_gemma":[0.0001547085,0.0001847009,0.0003113588,0.0001340794,0.0002652988,0.0003690833,0.0002162711,0.0009050402,0.0003883381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007360076,"about_ca_system_score_gemma":0.0003947376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001711971,"about_ca_topic_score_gemma":0.003272346,"domain_scores_codex":[0.9998479,0.000030049,0.00001606932,0.00003226543,0.00003701261,0.00003664397],"domain_scores_gemma":[0.999874,0.00002528356,0.00002459065,0.00002258649,0.00001598967,0.00003759524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002526618,0.0003087063,0.0005344232,0.00004571396,0.000005995275,0.0001188692,0.00002978939,0.0001299416,0.9969093,0.0001447403,0.00007926267,0.001440654],"study_design_scores_gemma":[0.0001355068,0.01278873,0.01300175,0.00002397995,0.000055521,0.001395447,0.0001122745,0.002115439,0.9635044,0.0001457231,0.006703267,0.00001809218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949979,0.001372377,0.001123805,0.0000983174,0.00003129711,0.000201423,0.0005784267,0.00004828207,0.001548281],"genre_scores_gemma":[0.9877118,0.002426536,0.002738871,0.00005310995,0.00001360666,0.0003072688,0.001339589,0.0000204342,0.005388646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711971,"threshold_uncertainty_score":0.005340159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07367733210390925,"score_gpt":0.3561156159404734,"score_spread":0.2824382838365641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}