{"id":"W2035129407","doi":"10.1002/ijc.10917","title":"Development of resistance to vincristine and doxorubicin in neuroblastoma alters malignant properties and induces additional karyotype changes: A preclinical model","year":2003,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Grantová Agentura České Republiky; Hilfe für krebskranke Kinder Frankfurt; Frankfurter Stiftung für krebskranke Kinder","keywords":"Neuroblastoma; Vincristine; Cell culture; Cytotoxic T cell; Doxorubicin; Cancer research; Cisplatin; Biology; P-glycoprotein; Karyotype; clone (Java method); Drug resistance; Chemotherapy; In vitro; Multiple drug resistance; Cyclophosphamide; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648519,0.0000868541,0.0001972316,0.000233045,0.00001787443,0.00001267768,0.000070703,0.00002513362,0.00008970131],"category_scores_gemma":[0.000245332,0.0000637972,0.0000227676,0.00007106648,0.00005791053,0.00007539201,0.00003524689,0.0001272548,8.199676e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001000296,"about_ca_system_score_gemma":0.0004035597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007186723,"about_ca_topic_score_gemma":0.000301993,"domain_scores_codex":[0.9988849,0.00003299206,0.0003589132,0.0001299506,0.0004760105,0.0001172928],"domain_scores_gemma":[0.9992914,0.00006356918,0.0001476855,0.00004355955,0.0003164258,0.0001373658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03877529,0.00284684,0.04390413,0.0006946027,0.002543149,0.002293047,0.007254337,0.0009397042,0.8132721,0.001208812,0.00987558,0.07639243],"study_design_scores_gemma":[0.0178635,0.002994527,0.419916,0.01053561,0.0001701721,0.001094963,0.0005561502,0.001148445,0.5165342,0.0009049071,0.02771618,0.0005653207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968802,0.0006078226,0.00005175064,0.002076499,0.00008242068,0.0001305558,0.00005130393,0.000002162755,0.0001172391],"genre_scores_gemma":[0.9945977,0.0002666332,0.004474604,0.0003550015,0.0000501685,0.00002276664,0.000002635638,0.000008831999,0.0002217079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3760119,"threshold_uncertainty_score":0.2601574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07367733210390925,"score_gpt":0.3561156159404734,"score_spread":0.2824382838365641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}