{"id":"W2035149130","doi":"10.1006/jmbi.2000.4073","title":"Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich’s ataxia","year":2000,"lang":"en","type":"letter","venue":"Journal of Molecular Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of General Medical Sciences; University of Houston; Medical Research Council; W. M. Keck Foundation","keywords":"Frataxin; Trinucleotide repeat expansion; Myotonic dystrophy; Antiparallel (mathematics); Genetics; DNA; Duplex (building); Biology; Repeated sequence; Ataxia; Spinocerebellar ataxia; Gene; Chemistry; Molecular biology; Biochemistry; Genome; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004441983,0.0004104336,0.0006955906,0.0003336685,0.001072428,0.0006716925,0.000675479,0.002109542,0.003278422],"category_scores_gemma":[0.001791991,0.0005035753,0.0005162447,0.0001599154,0.000507459,0.0006181655,0.0005165873,0.001702501,0.001072546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003435921,"about_ca_system_score_gemma":0.0002369672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002330412,"about_ca_topic_score_gemma":0.00033375,"domain_scores_codex":[0.9996144,0.00008825427,0.00003605632,0.0001320805,0.00006997051,0.00005920338],"domain_scores_gemma":[0.9986984,0.0005532981,0.0001879745,0.0002335728,0.00009322447,0.0002335305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003630731,0.0004176962,0.00268411,0.0003114863,0.000120955,0.02551892,0.0007004654,0.001584186,0.9449254,0.005441891,0.00392033,0.01074377],"study_design_scores_gemma":[0.0005409374,0.001901434,0.007967437,0.00003601309,0.0002167731,0.02475376,0.0003163846,0.01421919,0.9244806,0.008094598,0.01736058,0.0001124065],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780749,0.001094992,0.009969034,0.00241785,0.001688616,0.0001111855,0.0002322184,0.0004093935,0.006001745],"genre_scores_gemma":[0.991246,0.000178647,0.004121901,0.001093102,0.0002946101,0.00007941364,0.0002276861,0.00004862905,0.002710014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003278422,"threshold_uncertainty_score":0.01096743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246026192381253,"score_gpt":0.2758577203740587,"score_spread":0.2533974584502462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}