{"id":"W2035149130","doi":"10.1006/jmbi.2000.4073","title":"Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich’s ataxia","year":2000,"lang":"en","type":"letter","venue":"Journal of Molecular Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of General Medical Sciences; University of Houston; Medical Research Council; W. M. Keck Foundation","keywords":"Frataxin; Trinucleotide repeat expansion; Myotonic dystrophy; Antiparallel (mathematics); Genetics; DNA; Duplex (building); Biology; Repeated sequence; Ataxia; Spinocerebellar ataxia; Gene; Chemistry; Molecular biology; Biochemistry; Genome; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547116,0.0002420049,0.0006951994,0.0005144693,0.00002051042,0.00001023638,0.0003663461,0.0003119892,0.00004944805],"category_scores_gemma":[0.0006104973,0.00020979,0.0001959874,0.0002335275,0.0002492841,0.00006676496,0.00007067484,0.0006265846,0.00000180947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002680911,"about_ca_system_score_gemma":0.0001192582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001010293,"about_ca_topic_score_gemma":0.00000277741,"domain_scores_codex":[0.9972075,0.0008808494,0.00108298,0.0003019203,0.0002727702,0.0002539984],"domain_scores_gemma":[0.9980277,0.0001850463,0.001291386,0.0002942753,0.0001437358,0.00005789728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001920144,0.0000622724,0.000224081,0.00008478201,0.00001909197,0.0005790052,0.00007921016,0.0003465858,0.9878511,0.00003796151,0.01001465,0.0005091936],"study_design_scores_gemma":[0.001363271,0.0007930118,0.001620528,0.0001196161,0.00007240407,0.00040619,0.00001279167,0.00008085278,0.9834884,0.0007761007,0.0110488,0.0002179748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856959,0.0009487992,0.0005917164,0.01218355,0.0001376339,0.0002279971,0.0001002431,0.000004491319,0.0001096733],"genre_scores_gemma":[0.9631534,0.0008912229,0.0009168491,0.03474319,0.000162673,0.000005604476,0.00003997531,0.00003614312,0.00005092728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02255964,"threshold_uncertainty_score":0.8554988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02246026192381253,"score_gpt":0.2758577203740587,"score_spread":0.2533974584502462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}