{"id":"W2035194994","doi":"10.1038/cr.2015.16","title":"SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer","year":2015,"lang":"en","type":"article","venue":"Cell Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; KWF Kankerbestrijding","keywords":"Biology; Cancer research; Gefitinib; Gene knockdown; Lung cancer; Transcription factor; Chromatin remodeling; Carcinogenesis; Suppressor; Epidermal growth factor receptor; Cyclin-dependent kinase 8; Signal transduction; Chromatin; Chromatin immunoprecipitation; Notch signaling pathway; Cancer; Cell biology; Gene expression; Cell culture; Gene; Genetics; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008607488,0.00009028875,0.0001186716,0.00009974879,0.00005997907,0.0000506801,0.0001062921,0.000103067,0.00001190264],"category_scores_gemma":[0.0003309389,0.00007757129,0.00001485321,0.0001066083,0.00008864941,0.000004802301,0.0002630756,0.0001386729,0.000001668164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003530328,"about_ca_system_score_gemma":0.0001862263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003716431,"about_ca_topic_score_gemma":0.000128665,"domain_scores_codex":[0.9987829,0.0002244481,0.000129691,0.000330791,0.0002428305,0.0002893234],"domain_scores_gemma":[0.9993349,0.00008402886,0.00001759711,0.0002014521,0.0001489084,0.000213113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000513178,0.00002332711,0.00973026,0.00005782284,0.000004856837,0.000004956091,0.0003311968,0.00008331036,0.9693712,0.000002254961,0.01651909,0.003358558],"study_design_scores_gemma":[0.001416314,0.000283293,0.001128536,0.0001171674,0.000004288463,0.000003117618,0.000599912,0.0005420598,0.9514786,0.00005559391,0.04421871,0.0001523995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803662,0.01768978,0.00003943898,0.0003103007,0.00005198558,0.0002491178,0.00001446023,0.000005007955,0.001273714],"genre_scores_gemma":[0.9962433,0.001246117,0.0002766832,0.00007209468,0.0001412648,0.00008329897,0.000008265693,0.00001539542,0.001913586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02769962,"threshold_uncertainty_score":0.3163265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05158676078157883,"score_gpt":0.3934399372481734,"score_spread":0.3418531764665946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}