{"id":"W2035194994","doi":"10.1038/cr.2015.16","title":"SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer","year":2015,"lang":"en","type":"article","venue":"Cell Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; KWF Kankerbestrijding","keywords":"Biology; Cancer research; Gefitinib; Gene knockdown; Lung cancer; Transcription factor; Chromatin remodeling; Carcinogenesis; Suppressor; Epidermal growth factor receptor; Cyclin-dependent kinase 8; Signal transduction; Chromatin; Chromatin immunoprecipitation; Notch signaling pathway; Cancer; Cell biology; Gene expression; Cell culture; Gene; Genetics; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731319,0.0002226107,0.0002928704,0.0003803266,0.0001491439,0.000311835,0.0002110886,0.0001984663,0.001024418],"category_scores_gemma":[0.0001483122,0.0001764032,0.0001724125,0.0001799757,0.0002178284,0.0001447973,0.0001606812,0.0003684147,0.0004642993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003876559,"about_ca_system_score_gemma":0.0001866594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005628998,"about_ca_topic_score_gemma":0.001457677,"domain_scores_codex":[0.999874,0.00002540488,0.00001541123,0.00002313202,0.00003358049,0.00002848629],"domain_scores_gemma":[0.9998831,0.00001911729,0.00003477328,0.00001640197,0.0000126603,0.00003395318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230252,0.00002761364,0.0004434418,0.00001389481,0.000003767377,0.00003608707,0.000008041072,0.00004814045,0.997954,0.00004943038,0.00004637474,0.00124613],"study_design_scores_gemma":[0.00002695581,0.0003800261,0.01865186,0.000003559326,0.00001615811,0.0004188801,0.00003532313,0.001135793,0.9757263,0.00005025166,0.003550182,0.000004632639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950274,0.002731926,0.0007249194,0.0001058399,0.00001825262,0.00001355601,0.0002708533,0.00009989891,0.001007392],"genre_scores_gemma":[0.9971672,0.0006266288,0.0002584906,0.00002478769,0.000004705225,0.00001068619,0.0003711793,0.00001416084,0.001522159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001024418,"threshold_uncertainty_score":0.003427029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05158676078157883,"score_gpt":0.3934399372481734,"score_spread":0.3418531764665946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}