{"id":"W2035219498","doi":"10.1371/journal.pbio.1001465","title":"Neurons Refine the Caenorhabditis elegans Body Plan by Directing Axial Patterning by Wnts","year":2013,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; National Institute of General Medical Sciences; University of British Columbia; National Institutes of Health; Ontario Institute for Cancer Research; Genome British Columbia; Government of Ontario; Oklahoma Medical Research Foundation; Genome Canada","keywords":"Biology; Wnt signaling pathway; Caenorhabditis elegans; Body plan; Gastrulation; Epidermis (zoology); Ectopic expression; Netrin; Cell biology; Chordate; Developmental biology; Axon guidance; Zebrafish; Neuroscience; Caenorhabditis; Anatomy; Axon; Frizzled; Nervous system; Signal transduction; Gene; Genetics; Vertebrate; Embryo; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216718,0.000249991,0.0002162514,0.0000254656,0.0002484191,0.00005082045,0.0004323493,0.0002480376,0.0001704653],"category_scores_gemma":[0.0001299137,0.0001952132,0.00007292712,0.00005137343,0.0001700277,0.000005028896,0.0002019153,0.0002530979,0.00009516147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001288961,"about_ca_system_score_gemma":0.00002713554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007343622,"about_ca_topic_score_gemma":0.0001133387,"domain_scores_codex":[0.9984008,0.000194973,0.0002679994,0.0005216201,0.00009340984,0.0005212186],"domain_scores_gemma":[0.9992028,0.00005067669,0.0001274243,0.0004469249,0.00006670842,0.0001054059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007724073,0.00006736039,0.02103001,0.000007371242,0.00006689766,0.000001145052,0.000156252,0.00000426976,0.9413745,0.00000784961,0.03596333,0.001313276],"study_design_scores_gemma":[0.0007923149,0.0009232578,0.00844401,0.00001425553,0.00007794381,0.00005625452,0.000168551,0.000389992,0.8277778,0.0001611126,0.1605054,0.0006891325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950056,0.0007820513,0.00126771,0.001499289,0.0003607368,0.0002566843,0.0001577091,0.00004126564,0.000628975],"genre_scores_gemma":[0.9954821,0.0002303267,0.0001287432,0.001817625,0.0004905012,0.00006162797,0.0007448379,0.00004640952,0.000997848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1245421,"threshold_uncertainty_score":0.7960563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008894184818396766,"score_gpt":0.2074475811747043,"score_spread":0.1985533963563075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}