{"id":"W2035220761","doi":"10.1016/j.semcdb.2012.01.011","title":"Notch ligand endocytosis: Mechanistic basis of signaling activity","year":2012,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Jonsson Cancer Center Foundation; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Endocytic cycle; Endocytosis; Notch signaling pathway; Biology; Cell biology; Notch proteins; Hes3 signaling axis; Signal transduction; Cyclin-dependent kinase 8; Dynamin; Internalization; Cell signaling; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007604467,0.001002138,0.001362002,0.0008714707,0.0002099249,0.001670325,0.001560978,0.001758348,0.001224597],"category_scores_gemma":[0.0004247925,0.0003620345,0.0003569693,0.001116684,0.001385688,0.001625943,0.0009816175,0.001889627,0.00126362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001231682,"about_ca_system_score_gemma":0.0008191632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004255125,"about_ca_topic_score_gemma":0.0004722979,"domain_scores_codex":[0.9998215,0.00002073827,0.00002396168,0.00004926456,0.00005545422,0.00002919101],"domain_scores_gemma":[0.9998739,0.00004997845,0.00001568988,0.000009800758,0.00003075887,0.00001983532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003826302,0.00006493411,0.000365607,0.008070982,0.0001143168,0.0008060825,0.00007508268,0.001432538,0.03981894,0.04131808,0.02369196,0.8838589],"study_design_scores_gemma":[0.00005598049,0.00008337895,0.001495185,0.001103393,0.0001757099,0.00316428,0.0001449037,0.0007584659,0.01519934,0.01942382,0.958338,0.00005760502],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001239486,0.990702,0.002226263,0.001296886,0.0006803162,0.000007781616,0.00006968019,0.00004292966,0.003734538],"genre_scores_gemma":[0.007337927,0.9884546,0.001026408,0.0005785716,0.0003989691,0.00001429614,0.00009730556,0.000006226281,0.002085703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001758348,"threshold_uncertainty_score":0.008936524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02387628474476043,"score_gpt":0.2815276263986235,"score_spread":0.2576513416538631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}