{"id":"W2035236902","doi":"10.1159/000325730","title":"Pharmacological Enhancement of ex vivo Gene Therapy Neuroprotection in a Rodent Model of Retinal Degeneration","year":2011,"lang":"en","type":"article","venue":"Ophthalmic Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Neuroprotection; Ex vivo; Retinal degeneration; Rodent model; In vivo; Retinal; Neuroscience; Genetic enhancement; Medicine; Biology; Retina; Pathology; Gene; Pharmacology; Ophthalmology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006708841,0.00007886761,0.000106096,0.0001036684,0.00003145542,0.00000429365,0.000163349,0.00008011688,0.0001497657],"category_scores_gemma":[0.00003846449,0.00006908422,0.00004110356,0.0001547992,0.0000942136,0.000004258885,0.00007953058,0.0001101016,0.000003500922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001608997,"about_ca_system_score_gemma":0.00009936527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008294181,"about_ca_topic_score_gemma":0.000005192807,"domain_scores_codex":[0.9988452,0.000175401,0.0002511413,0.0002419687,0.0002869902,0.0001993323],"domain_scores_gemma":[0.9995872,0.000006718788,0.00006136201,0.0001405868,0.0001691734,0.0000349671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008580572,0.0002599073,0.004862389,0.00001378734,0.000009619594,0.000002980157,0.0001416451,0.0001608759,0.9925684,0.00002436991,0.00008378891,0.001014209],"study_design_scores_gemma":[0.0005022223,0.0007801444,0.004599433,0.000008037031,0.000001518615,0.000004480754,0.00004301556,0.001582402,0.9921938,0.0001781751,0.00004056808,0.00006618592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935688,0.0002831848,0.001048289,0.00002187473,0.00003214305,0.0003498765,0.000002377411,0.000001660443,0.004691843],"genre_scores_gemma":[0.99665,0.001322547,0.00143546,0.000008861605,0.00002238371,0.00006311121,0.00001484109,0.000008326141,0.0004745143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004217329,"threshold_uncertainty_score":0.2817173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1631339550720394,"score_gpt":0.3742878602304405,"score_spread":0.2111539051584011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}