{"id":"W2035246749","doi":"10.1158/1538-7445.prca2012-a19","title":"Abstract A19: Blocking autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; LNCaP; Cancer research; Autophagy; PTEN; Prostate cancer; Apoptosis; Cell growth; Medicine; Cancer; Signal transduction; Chemistry; Biology; Cell biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009369335,0.0003944182,0.0004205559,0.000286306,0.0001824586,0.0002605921,0.0002369398,0.000264165,0.002087972],"category_scores_gemma":[0.00006318285,0.0001205382,0.0003430787,0.0002429468,0.0001903703,0.000157021,0.000120543,0.0006222252,0.0005364298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565567,"about_ca_system_score_gemma":0.0002917044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007605956,"about_ca_topic_score_gemma":0.001155752,"domain_scores_codex":[0.9998959,0.00001005036,0.00001769733,0.00002149635,0.00003283055,0.00002208056],"domain_scores_gemma":[0.999954,0.000006685946,0.00001282361,0.000007329879,0.000006545882,0.00001260126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005644066,0.0001831252,0.0003093985,0.00008332034,0.00002170567,0.0000699007,0.00001225346,0.0001950321,0.9941927,0.00009986111,0.0002210975,0.004047201],"study_design_scores_gemma":[0.00008757064,0.001479833,0.002840378,0.000004795051,0.00003774392,0.0002268924,0.000009145448,0.0005285438,0.9925384,0.00002212613,0.002219907,0.000004715873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909974,0.003375735,0.001615702,0.0001732561,0.0001155879,0.00008108101,0.0009873823,0.0002518797,0.002401919],"genre_scores_gemma":[0.9936824,0.001607315,0.001408431,0.00005767821,0.00001939007,0.00004132995,0.001109233,0.00001956818,0.00205463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002087972,"threshold_uncertainty_score":0.006985009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08503292225527195,"score_gpt":0.3893040782431366,"score_spread":0.3042711559878646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}