{"id":"W2035248522","doi":"10.1042/bse0500161","title":"The P-glycoprotein multidrug transporter","year":2011,"lang":"en","type":"review","venue":"Essays in Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":490,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"ATP-binding cassette transporter; Transporter; ATP hydrolysis; Biochemistry; Efflux; Transmembrane protein; P-glycoprotein; Flippase; Chemistry; Lipid bilayer; Cyclic nucleotide-binding domain; Nucleotide; Biology; ATPase; Multiple drug resistance; Phospholipid; Enzyme; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003900618,0.000533257,0.001337165,0.00006756464,0.00009988108,0.00001860306,0.0004395223,0.0007028438,0.0002031593],"category_scores_gemma":[0.00002153584,0.0003139387,0.0006732254,0.0002704006,0.0001959304,0.00002130012,0.00002188482,0.0009937413,0.0000696673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227636,"about_ca_system_score_gemma":0.0003807912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001504574,"about_ca_topic_score_gemma":0.00001824074,"domain_scores_codex":[0.9978459,0.00003153628,0.0007993705,0.0005693608,0.000265053,0.0004887703],"domain_scores_gemma":[0.9986066,0.00005496981,0.0002263137,0.0009183254,0.00003875544,0.0001551023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007939863,0.0002190219,0.00001977441,0.03405072,0.0001968861,0.0005195587,0.0001053258,1.719145e-8,0.00008501597,0.0003189109,0.0007506863,0.9636547],"study_design_scores_gemma":[0.0004564422,0.0000157782,0.000005723853,0.01805889,0.000482933,0.00008274782,0.0000386308,4.176612e-7,0.001331477,0.0001197122,0.9790446,0.000362641],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003655886,0.9816599,0.00002348757,0.00004613055,0.0003706208,0.0008491873,0.00003288483,0.00006832389,0.01691292],"genre_scores_gemma":[0.000215084,0.9804829,0.0003245792,0.00002508731,0.0002641103,0.0003081347,0.0002510583,0.00009311508,0.01803587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9782939,"threshold_uncertainty_score":0.9999313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036713525977285,"score_gpt":0.3022675742609918,"score_spread":0.2719004390012189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}