{"id":"W2035267140","doi":"10.1021/bm801178f","title":"Effect of Poly(<i>N</i>-vinyl-pyrrolidone)-<i>block</i>-poly(<scp>d</scp>,<scp>l</scp>-lactide) as Coating Agent on the Opsonization, Phagocytosis, and Pharmacokinetics of Biodegradable Nanoparticles","year":2009,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Antibody opsonization; Chemistry; PEG ratio; Ethylene glycol; Nanoparticle; Protein adsorption; Phagocytosis; Adsorption; Nuclear chemistry; Polymer chemistry; In vivo; In vitro; Opsonin; Biochemistry; Organic chemistry; Materials science; Nanotechnology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001380816,0.0005750295,0.0006995891,0.0002420968,0.0003802234,0.000191087,0.0006934248,0.0001617181,0.0000263255],"category_scores_gemma":[0.001969486,0.0004362467,0.0001795073,0.0009463779,0.000567382,0.0002601892,0.0002147847,0.0001702895,0.00009085306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007603523,"about_ca_system_score_gemma":0.0001378093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001963307,"about_ca_topic_score_gemma":0.000008085798,"domain_scores_codex":[0.9956961,0.0007985203,0.0009721747,0.0007345089,0.0009219635,0.0008766833],"domain_scores_gemma":[0.9950529,0.002864315,0.000753207,0.000761641,0.0002702417,0.0002977266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000860793,0.0004049678,0.0006480445,0.0001322134,0.00005405535,0.00003791392,0.0007135107,0.00008750039,0.9932684,0.0005035104,0.001941127,0.002122657],"study_design_scores_gemma":[0.001637217,0.001643572,0.0004858366,0.0001956202,0.0002289386,0.00005266114,0.000353435,0.0008554436,0.9934034,0.0001981375,0.0008016103,0.0001441093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913877,0.006233633,0.0001578081,0.0002959285,0.0002825753,0.0007851597,0.0001525234,0.0001702848,0.0005343354],"genre_scores_gemma":[0.9981022,0.0002322939,0.0007198333,0.0005943482,0.00009135655,0.00003828609,0.00001619346,0.00006349868,0.0001419353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006714503,"threshold_uncertainty_score":0.9998089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073262616615488,"score_gpt":0.2495957003646462,"score_spread":0.2388630741984913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}