{"id":"W2035267140","doi":"10.1021/bm801178f","title":"Effect of Poly(<i>N</i>-vinyl-pyrrolidone)-<i>block</i>-poly(<scp>d</scp>,<scp>l</scp>-lactide) as Coating Agent on the Opsonization, Phagocytosis, and Pharmacokinetics of Biodegradable Nanoparticles","year":2009,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Antibody opsonization; Chemistry; PEG ratio; Ethylene glycol; Nanoparticle; Protein adsorption; Phagocytosis; Adsorption; Nuclear chemistry; Polymer chemistry; In vivo; In vitro; Opsonin; Biochemistry; Organic chemistry; Materials science; Nanotechnology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187888,0.00037104,0.0002540566,0.0001095411,0.00009623126,0.000208617,0.0001823113,0.0002442782,0.0004758734],"category_scores_gemma":[0.0002531465,0.0001474125,0.0001713644,0.00009774009,0.0002002839,0.000157554,0.00009520742,0.0002396227,0.0001951468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374795,"about_ca_system_score_gemma":0.0002325642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009653938,"about_ca_topic_score_gemma":0.0009098843,"domain_scores_codex":[0.9998816,0.00003169407,0.00001090802,0.00002812388,0.00001680796,0.00003071245],"domain_scores_gemma":[0.9998043,0.00007722529,0.00005114161,0.00001363809,0.00001771517,0.00003599243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006376795,0.00009882871,0.00007278851,0.00004966065,0.00000731002,0.00002539976,0.00001292551,0.0002185792,0.9971534,0.00003027698,0.00002341014,0.001669717],"study_design_scores_gemma":[0.00001629408,0.0009656257,0.0007902551,0.000001773782,0.000009777355,0.00002894439,0.000002894373,0.0006978614,0.9972011,0.000005915997,0.0002757251,0.000003830804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967223,0.0008876696,0.001084556,0.00002882542,0.00002887401,0.00002639061,0.00006792233,0.00005767199,0.001095825],"genre_scores_gemma":[0.9966956,0.0005359785,0.001552147,0.00002309106,0.00001107979,0.00001635811,0.00006356679,0.00002057629,0.001081599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009653938,"threshold_uncertainty_score":0.001919568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073262616615488,"score_gpt":0.2495957003646462,"score_spread":0.2388630741984913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}