{"id":"W2035301061","doi":"10.1038/sj.onc.1210522","title":"Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr–Met, involves exclusion from the endocytic degradative pathway","year":2007,"lang":"en","type":"article","venue":"Oncogene","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Endocytic cycle; Cell biology; Receptor tyrosine kinase; Internalization; Transmembrane protein; Ubiquitin; Endosome; Signal transduction; Receptor Protein-Tyrosine Kinases; Chromosomal translocation; Ubiquitin ligase; Tyrosine kinase; Endocytosis; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196785,0.0002928679,0.0001554641,0.0001786724,0.0003155344,0.0005505038,0.0001520058,0.0002638821,0.0006857102],"category_scores_gemma":[0.000171822,0.0001155051,0.0001872333,0.0001051282,0.0001954668,0.0003608457,0.0002354499,0.0004283767,0.0004451544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005677996,"about_ca_system_score_gemma":0.0002538256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005043407,"about_ca_topic_score_gemma":0.0008379115,"domain_scores_codex":[0.9998093,0.00002896095,0.00001173781,0.00002538834,0.0000713414,0.00005324174],"domain_scores_gemma":[0.9998724,0.00002314414,0.00003994642,0.00001288593,0.00002183635,0.00002973748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001683969,0.00001510662,0.0004353107,0.0000222681,0.000003946702,0.000189838,0.00001149261,0.00006655589,0.9957979,0.001082154,0.00008048403,0.002126427],"study_design_scores_gemma":[0.00001156183,0.00005899967,0.007009339,0.000003626611,0.000007300416,0.001581595,0.00002918354,0.001896172,0.9855095,0.0003399918,0.003548351,0.00000452646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876432,0.002808516,0.006553778,0.0003100174,0.00002635326,0.00001193879,0.0001770812,0.000086361,0.002382688],"genre_scores_gemma":[0.9951897,0.0008534575,0.001313284,0.00002818483,0.000009371466,0.000006712934,0.0002645146,0.00001349232,0.002321229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006857102,"threshold_uncertainty_score":0.004119635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854688071781999,"score_gpt":0.2461407192830434,"score_spread":0.2275938385652234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}