{"id":"W2035301061","doi":"10.1038/sj.onc.1210522","title":"Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr–Met, involves exclusion from the endocytic degradative pathway","year":2007,"lang":"en","type":"article","venue":"Oncogene","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Endocytic cycle; Cell biology; Receptor tyrosine kinase; Internalization; Transmembrane protein; Ubiquitin; Endosome; Signal transduction; Receptor Protein-Tyrosine Kinases; Chromosomal translocation; Ubiquitin ligase; Tyrosine kinase; Endocytosis; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000650561,0.0002309234,0.0001970389,0.00003345978,0.0002606091,0.00001891709,0.000437337,0.0001961241,0.0001103687],"category_scores_gemma":[0.0003541893,0.0001392292,0.0001834663,0.0002625193,0.0001495779,0.000009832673,0.0003607689,0.0001576877,0.00001478286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006518937,"about_ca_system_score_gemma":0.0001970253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001836106,"about_ca_topic_score_gemma":0.0001190494,"domain_scores_codex":[0.9983871,0.0002533518,0.00036162,0.0003844637,0.0003299811,0.0002834588],"domain_scores_gemma":[0.9986807,0.00009107644,0.0003253867,0.0006522014,0.0001722848,0.00007841603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002967917,0.0001050174,0.0004520209,0.00001105178,0.00004950636,0.000001085628,0.000237903,0.000004044137,0.9805634,0.0002231019,0.0003832477,0.0176728],"study_design_scores_gemma":[0.000733425,0.0004082382,0.0006911124,0.00009883943,0.00002636611,0.000002565933,0.0003283461,0.000006465302,0.963697,0.0002973259,0.03353452,0.0001757485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949946,0.001288467,0.001377305,0.0001939717,0.0001943899,0.0009725503,0.0001577967,0.00001557385,0.0008053793],"genre_scores_gemma":[0.9958126,0.00009310889,0.002250929,0.0003507518,0.0004934405,0.00006411572,0.0002841146,0.00003263519,0.0006183177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03315127,"threshold_uncertainty_score":0.5677603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854688071781999,"score_gpt":0.2461407192830434,"score_spread":0.2275938385652234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}