{"id":"W2035311761","doi":"10.1007/s00424-014-1501-7","title":"State-dependent blocker interactions with the CFTR chloride channel: implications for gating the pore","year":2014,"lang":"en","type":"article","venue":"Pflügers Archiv - European Journal of Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Chloride channel; Gating; Cystic fibrosis transmembrane conductance regulator; Biophysics; Permeation; Patch clamp; Channel blocker; Ion channel; Membrane; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007486196,0.0002842834,0.0006825845,0.0001953509,0.0006804905,0.001945058,0.0007725018,0.001120859,0.004983802],"category_scores_gemma":[0.003147579,0.0003943205,0.0005841536,0.0001755151,0.0007547908,0.001758823,0.0008034605,0.001193191,0.0008303235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005266264,"about_ca_system_score_gemma":0.0005487577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00042184,"about_ca_topic_score_gemma":0.0007381412,"domain_scores_codex":[0.9993367,0.0001888263,0.00004535342,0.00009705142,0.0001737371,0.0001583533],"domain_scores_gemma":[0.9991352,0.000465307,0.0001575514,0.00008165192,0.00009159209,0.00006869646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001327817,0.0001340649,0.002691943,0.000216011,0.0001312913,0.000559151,0.0004439254,0.001235659,0.9774785,0.007384697,0.001174242,0.007222656],"study_design_scores_gemma":[0.00052455,0.002478117,0.02182619,0.0001418486,0.0005763867,0.002671588,0.0008400925,0.04173238,0.9050562,0.01079571,0.01314151,0.0002155133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841016,0.003474553,0.005197235,0.001559104,0.0002841632,0.00004720001,0.0002056312,0.000147969,0.004982615],"genre_scores_gemma":[0.9961467,0.001199718,0.001145177,0.0003438792,0.00004736745,0.0000189098,0.000150927,0.00005331921,0.0008939373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004983802,"threshold_uncertainty_score":0.01667249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988074127391977,"score_gpt":0.300090098596222,"score_spread":0.2802093573223023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}