{"id":"W2035366758","doi":"10.1128/jcm.00682-12","title":"Recovery of Influenza B Virus with the H273Y Point Mutation in the Neuraminidase Active Site from a Human Patient","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Microbiology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Mount Sinai Hospital; Public Health Agency of Canada; University of Toronto; Public Health Ontario","funders":"Centers for Disease Control and Prevention; GlaxoSmithKline","keywords":"Oseltamivir; Zanamivir; Neuraminidase; Virology; Neuraminidase inhibitor; Human influenza; Point mutation; Mutation; Influenza A virus; Influenzavirus B; Virus; Microbiology; Resistance mutation; Drug resistance; Biology; Orthomyxoviridae; Medicine; Coronavirus disease 2019 (COVID-19); Gene; Genetics; Polymerase chain reaction; Infectious disease (medical specialty); Disease; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002192919,0.0004376896,0.0003905739,0.0002511712,0.0007192146,0.0004769983,0.0002591318,0.000828355,0.001562257],"category_scores_gemma":[0.0007602333,0.0001950339,0.0004450748,0.0001193993,0.0003460334,0.0002373712,0.0003473336,0.001186498,0.0007857599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717454,"about_ca_system_score_gemma":0.0002534111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001983094,"about_ca_topic_score_gemma":0.001098931,"domain_scores_codex":[0.9997521,0.00004363746,0.00002264741,0.00007279032,0.0000617661,0.00004710538],"domain_scores_gemma":[0.9997886,0.00005830735,0.00001813357,0.0000412535,0.00003157766,0.00006220972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.001935885,0.0008310263,0.09247208,0.0002253792,0.0001764672,0.1776637,0.003205947,0.0005591434,0.6781647,0.001261911,0.006955484,0.03654829],"study_design_scores_gemma":[0.0001997976,0.00556527,0.1227688,0.00007823743,0.0001495826,0.4873158,0.001867236,0.002404895,0.3447277,0.0003906705,0.03444669,0.00008535375],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937715,0.0005308921,0.001795102,0.0006510041,0.00008869317,0.0001138298,0.0005663264,0.00004930995,0.002433337],"genre_scores_gemma":[0.9942905,0.0003486466,0.001602429,0.000329447,0.00003970978,0.00002818999,0.000767563,0.00001970769,0.002573858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001983094,"threshold_uncertainty_score":0.005226314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.116614374387332,"score_gpt":0.4429299496540706,"score_spread":0.3263155752667386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}