{"id":"W2035368412","doi":"10.1021/ac5011684","title":"Development of a Universal Metabolome-Standard Method for Long-Term LC–MS Metabolome Profiling and Its Application for Bladder Cancer Urine-Metabolite-Biomarker Discovery","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Metabolome; Metabolomics; Chemistry; Reproducibility; Biomarker discovery; Urine; Chromatography; Metabolite; Mass spectrometry; Sample preparation; Proteomics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000581143,0.0002951172,0.0005953145,0.00005256679,0.000125893,0.00002745393,0.0002019818,0.0001950794,0.00001284676],"category_scores_gemma":[0.0002306169,0.000261542,0.0002118318,0.0001543985,0.00009263175,0.00001370349,0.0001732956,0.00008274958,3.417501e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000268876,"about_ca_system_score_gemma":0.0001433999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003428995,"about_ca_topic_score_gemma":0.000007638629,"domain_scores_codex":[0.9982751,0.00002673561,0.0004644175,0.0006628512,0.0001779728,0.0003929312],"domain_scores_gemma":[0.9989781,0.00008533381,0.0002180908,0.000296386,0.0002882596,0.000133775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004164909,0.00007155862,0.001235195,0.0004084553,0.0009186193,1.724018e-7,0.00001881396,0.000009405631,0.9890977,0.003913056,0.00004252994,0.003867989],"study_design_scores_gemma":[0.001384064,0.00005146738,0.001644739,0.00001186568,0.0005753397,0.000002502398,0.00004842124,0.002591291,0.9676551,0.0002614504,0.02542632,0.0003474031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7392712,0.004051108,0.2551792,0.0001501214,0.0000614431,0.0005910801,0.0003065268,0.00001364092,0.0003756827],"genre_scores_gemma":[0.942349,0.0006375426,0.05408416,0.00008728723,0.0003374637,0.0004333305,0.0005137548,0.00005228971,0.001505245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2030777,"threshold_uncertainty_score":0.9999837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627139580820798,"score_gpt":0.3112906757652878,"score_spread":0.2950192799570798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}